Featured Research

from universities, journals, and other organizations

Most Adults Under 50 Unlikely To Need Colorectal Screening, Study Suggests

Date:
September 30, 2008
Source:
Johns Hopkins Medical Institutions
Summary:
Young adults without a family history of bowel disease are unlikely to develop adenomas, the colorectal polyps most likely to lead to cancer, according to new research. The finding supports current cancer screening guidelines recommending adults in general undergo screening colonoscopies starting at age 50.

Young adults without a family history of bowel disease are unlikely to develop adenomas, the colorectal polyps most likely to lead to cancer, according to new research directed by scientists at the Johns Hopkins Kimmel Cancer Center. The finding supports current cancer screening guidelines recommending adults in general undergo screening colonoscopies starting at age 50.

Related Articles


The new study, published in the September issue of the journal Clinical Gastroenterology and Hepatology, also showed that white patients more often had adenomas on the left side of the colon, whereas African Americans had lesions more often on the right side. The take-home lesson, Giardiello says, is that screening and diagnostic evaluations of African Americans should include a colonoscopy rather than a sigmoidoscopy, because the latter evaluates only part of the colon.

The Hopkins study assessed the "natural history" and occurrence of colorectal polyps by reviewing records of 3,558 autopsies performed at The Johns Hopkins Hospital between 1985 and 2004 on patients aged 20 to 89. The review, called an "epidemiologic necropsy," categorized patients by sex, race and 10-year age groups, then compared the prevalence and location of adenomas between younger adults (ages 20 to 49) and older adults (ages 50 to 89).

The review identified a low but increasing prevalence ofcolorectal adenomas -- from 1.72 percent to 3.59 percent – from the third to the fifth decade of life, with the presence of adenomas sharply increasing after age 50. Prevalence ranged from 10 to 12 percent from the sixth to ninth decade of life.

"Our study affirmed that the greatest increase in prevalence was in older adults, abruptly starting in the sixth decade," says Francis M. Giardiello, M.D., professor of medicine, oncology and pathology, who directed the research. The average number of adenomas spotted in most young adults was one. In older adults, the average number of adenomas ranged from 1.6 to 1.9.

Most polyps detected in colorectal screenings qualify as adenomas, but there are also lower-risk lesions called "hyperplastic" which are not thought to lead to cancer, the researchers note.

The researchers found that in young adults, adenomas were slightly more prevalent in men than in women and in whites than in blacks. In older adults, the prevalence of adenomas also was greater in men than in women, but greater in blacks than in whites.

In addition, the study found that in both younger and older adults, the overall prevalence of left-sided adenomas was higher than right-sided adenomas. Compared with younger adults, older adults had an increased prevalence of adenomas on both sides of the colorectum, but a relatively greater prevalence of right-sided adenomas.

Colorectal cancer is the second leading cause of cancer-related death after lung cancer. Each U.S. citizen has a 6 percent lifetime risk of colorectal cancer. When colorectal cancer is diagnosed at an early stage, five-year survival rates are about 90 percent; however, less than 40 percent of patients present at an early stage.

The study was supported by The John G. Rangos, Sr. Charitable Foundation, The Clayton Fund and the National Institutes of Health.

Coauthors were Cheryl J. Pendergrass, Daniel L. Edelstein, Linda M. Hylind, Blaine T. Phillips, Christine Iacobuzio-Donahue, Katharine Romans, and Constance A. Griffin of Hopkins; Marcia Cruz-Correa of the University of Puerto Rico, San Juan; and Anne C. Tersmette and G. Johan A. Offerhaus of Utrecht Medical Center, the Netherlands.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Most Adults Under 50 Unlikely To Need Colorectal Screening, Study Suggests." ScienceDaily. ScienceDaily, 30 September 2008. <www.sciencedaily.com/releases/2008/09/080930154837.htm>.
Johns Hopkins Medical Institutions. (2008, September 30). Most Adults Under 50 Unlikely To Need Colorectal Screening, Study Suggests. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/09/080930154837.htm
Johns Hopkins Medical Institutions. "Most Adults Under 50 Unlikely To Need Colorectal Screening, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/09/080930154837.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins