Featured Research

from universities, journals, and other organizations

Saliva Proteins Could Help Detection Of Oral Cancer

Date:
October 2, 2008
Source:
American Association for Cancer Research
Summary:
Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects proteins in saliva, according to a report in the Oct. 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research. This work was led by David T. Wong, D.M.D., D.M.Sc., professor and associate dean for research, at the University of California, Los Angeles School of Dentistry.

Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects proteins in saliva, according to a report in the October 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research. This work was led by David T. Wong, D.M.D., D.M.Sc., professor and associate dean for research, at the University of California, Los Angeles School of Dentistry.

Previous studies have shown that saliva can be a useful diagnostic tool, but this is the first study to globally evaluate saliva protein levels from oral cancer patients. Since it is very simple to collect and process saliva fluids, the discovery of these biomarkers may lead to a useful clinical tool for noninvasive diagnosis of oral cancer in the future.

"This test is currently not available, but we are developing point-of-care microfluidic devices to detect these markers that we can use in clinical trials," said Shen Hu, Ph.D., assistant professor of Oral Biology and Proteomics at the University of California, Los Angeles School of Dentistry.

Wong, Hu and colleagues have been working as part of the National Institute of Dental and Craniofacial Research (NIDCR)'s Human Saliva Proteome Project, which focuses on identifying and cataloguing the proteomic components of saliva in healthy subjects. This work, also supported by NIDCR, demonstrates the first translational utility of the salivary proteome for oral cancer detection.

Researchers collected saliva samples from 64 patients with oral squamous cell carcinoma and 64 healthy patients.

Five candidate biomarkers were successfully validated using immunoassays: M2BP, MRP14, CD59, profilin and catalase.

The presence of these biomarkers confirmed the presence of oral cancer 93 percent of the time.

"I believe a test measuring these biomarkers will come to a point of regular use in the future," Hu said. "We have demonstrated a new approach for cancer biomarker discovery using saliva proteomics."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Saliva Proteins Could Help Detection Of Oral Cancer." ScienceDaily. ScienceDaily, 2 October 2008. <www.sciencedaily.com/releases/2008/10/081001093035.htm>.
American Association for Cancer Research. (2008, October 2). Saliva Proteins Could Help Detection Of Oral Cancer. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/10/081001093035.htm
American Association for Cancer Research. "Saliva Proteins Could Help Detection Of Oral Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/10/081001093035.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins