Featured Research

from universities, journals, and other organizations

Unique Properties Of Boron Harnessed To Develop New Drugs And Diagnostics

Date:
October 23, 2008
Source:
European Science Foundation
Summary:
Researchers are on the verge of unleashing the power of the element boron in a new generation of drugs and therapies, as decades of research begins to bear fruit. Boron has to date far been one of biology's best kept secrets, but is now attracting fast growing research interest and investment from the pharmaceutical industry in the quest for novel drugs to tackle cancer and infectious diseases, potentially overcoming limitations and side effects of current products.

Researchers are on the verge of unleashing the power of the element boron in a new generation of drugs and therapies, as decades of research begins to bear fruit. Boron has to date far been one of biology's best kept secrets, but is now attracting fast growing research interest and investment from the pharmaceutical industry in the quest for novel drugs to tackle cancer and infectious diseases, potentially overcoming limitations and side effects of current products.

Europe's response to the challenges and opportunities of boron chemistry in medicine was discussed at a recent workshop, Biobor - Exploring New Opportunities Of Boron Chemistry Towards Medicine.

"Yes, it became obvious during the workshop that there is now sufficient knowledge and enough compounds to support a broad program of screening in the quest for new antiviral and anticancer drugs containing essential boron components," said Lesnikowski. There was also scope for improving the application of BNCT to cancer, but besides these two therapeutic avenues, boron also has vast potential as the basis for compounds in diagnosis and biosensing, and also for novel bioorganic materials, said Lesnikowski.

The applications in bio sensing, biomaterials, and drug development all spring from the fundamental chemical properties of boron. All life is derived ultimately from the element carbon, which lies next to boron in the periodic table of elements, their respective atomic numbers being six and five. Boron compounds share some similarities with carbon but also have important differences. It is the combination of these similarities and differences that give boron its unique potential in medicine.

The important similarity is that boron, like carbon, combines with hydrogen to form stable compounds that can participate in biochemical reactions and syntheses. The key difference is that these compounds have distinctive geometrical shapes and electronic charge distributions with greater 3D complexity than their carbon based equivalents.

As Lesnikowski put it, while organic carbon molecules tend to comprise rings and chains, boron hydrides (compounds comprising mostly boron and hydrogen) are made up of clusters and cages. This 3D structure makes it possible to design molecules with specific charge distributions by varying their internal structure, and this in turn brings the potential to tune how each part of the structure relates to water molecules, and biomolecules present in living organisms - if a component is hydrophobic, meaning it repels water, it is well placed to enter cells by crossing the membrane. If it is hydrophilic, meaning water-loving, it will naturally be soluble in water. The hydrophobic/hydrophilic interactions also affect how a molecule makes contact and communication with target proteins and nucleic acids.

The fact that novel boron compounds will be unfamiliar to life has potential advantages for antibiotic drugs, since pathogens will be less able to develop resistance against them. "Also the kind of interactions would be somehow different from key-lock systems build up in living cell lines in nature for billions of years," said Lesnikowski. "We can thus anticipate that active substances would be less prone to development of resistance," said Lesnikowski. "This is an obvious advantage of boron drugs."

While eventually pathogens such as bacteria and viruses are capable of evolving resistance against almost any molecule that attacks them, Lesnikowski believed that it would take longer for this to happen in the case of boron based compounds which would therefore make it easier for humans to remain one step ahead rather than struggling to keep pace as at present.

Apart from lack of knowledge over the potential, development of boron compounds for medicine has been held back until now by the high cost of catalysts and born based intermediate compounds used in the synthesis. Another important recent development therefore was availability of lower cost intermediates in the synthesis processes, according to Lesnikowski.


Story Source:

The above story is based on materials provided by European Science Foundation. Note: Materials may be edited for content and length.


Cite This Page:

European Science Foundation. "Unique Properties Of Boron Harnessed To Develop New Drugs And Diagnostics." ScienceDaily. ScienceDaily, 23 October 2008. <www.sciencedaily.com/releases/2008/10/081021094210.htm>.
European Science Foundation. (2008, October 23). Unique Properties Of Boron Harnessed To Develop New Drugs And Diagnostics. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/10/081021094210.htm
European Science Foundation. "Unique Properties Of Boron Harnessed To Develop New Drugs And Diagnostics." ScienceDaily. www.sciencedaily.com/releases/2008/10/081021094210.htm (accessed July 24, 2014).

Share This




More Matter & Energy News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Robot Parking Valet Creates Stress-Free Travel

Robot Parking Valet Creates Stress-Free Travel

AP (July 23, 2014) 'Ray' the robotic parking valet at Dusseldorf Airport in Germany lets travelers to avoid the hassle of finding a parking spot before heading to the check-in desk. (July 23) Video provided by AP
Powered by NewsLook.com
Boeing Ups Outlook on 52% Profit Jump

Boeing Ups Outlook on 52% Profit Jump

Reuters - Business Video Online (July 23, 2014) Commercial aircraft deliveries rose seven percent at Boeing, prompting the aerospace company to boost full-year profit guidance- though quarterly revenues missed analyst estimates. Bobbi Rebell reports. Video provided by Reuters
Powered by NewsLook.com
Europe's Car Market on the Rebound?

Europe's Car Market on the Rebound?

Reuters - Business Video Online (July 23, 2014) Daimler kicks off a round of second-quarter earnings results from Europe's top carmakers with a healthy set of numbers - prompting hopes that stronger sales in Europe will counter weakness in emerging markets. Hayley Platt reports. Video provided by Reuters
Powered by NewsLook.com
9/11 Commission Members Warn of Terror "fatigue" Among American Public

9/11 Commission Members Warn of Terror "fatigue" Among American Public

Reuters - US Online Video (July 22, 2014) Ten years after releasing its initial report, members of the 9/11 Commission warn of the "waning sense of urgency" in combating terrorists attacks. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins