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How Did Glycine Significantly Decrease Liver Injury?

Date:
October 31, 2008
Source:
World Journal of Gastroenterology
Summary:
Chronic cholestasic liver diseases lead to liver injury and ultimately progress to portal fibrosis, cirrhosis, and end-stage liver disease requiring liver transplantation. A research group in the US and Germany investigated the effects of (dietary) glycine against oxidant-induced injury caused by bile duct ligation in rats. The study demonstrate that hepatic injury due to BDL is significantly reduced by dietary glycine and glycine decreases liver injury thru a direct effect on hepatocytes.

The nonessential amino acid glycine has been shown to be anti-inflammatory in several animal injury models. Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplantation. The influence of dietary glycine on oxidant-induced or cholestatic liver injury was not known.

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A research team led by Prof. Thurman from the University of North Carolina used a dietary and cholestatic model thru BDL in rats to address this question. They could demonstrate that hepatic injury due to BDL is significantly reduced by dietary glycine in rats. Moreover, the data indicated that glycine decreases liver injury under the conditions of experimental cholestasis thru a direct effect on hepatocytes. Surprisingly, Kupffer cells did not appear to play a major role in the pathological changes caused by cholestasis.

It is best known that Kupffer cells, the resident macrophages of the liver, are involved in several disease states, such as endotoxin shock, alcoholic liver diseases, and other toxicant-induced liver injury by releasing eicosanoids, inflammatory cytokines, and free radical species. Furthermore, in previous studies of the research team, a glycine-dependent chloride channel on the cell membrane of Kupffer cells and other macrophages that influence the activation process of these cells could be detected. But in the actual used cholestatic model no significant influence of this cell line on liver injury could be detected.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Froh et al. Dietary glycine blunts liver injury after bile duct ligation in rats. World Journal of Gastroenterology, 2008; 14 (39): 5996 DOI: 10.3748/wjg.14.5996

Cite This Page:

World Journal of Gastroenterology. "How Did Glycine Significantly Decrease Liver Injury?." ScienceDaily. ScienceDaily, 31 October 2008. <www.sciencedaily.com/releases/2008/10/081031112037.htm>.
World Journal of Gastroenterology. (2008, October 31). How Did Glycine Significantly Decrease Liver Injury?. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2008/10/081031112037.htm
World Journal of Gastroenterology. "How Did Glycine Significantly Decrease Liver Injury?." ScienceDaily. www.sciencedaily.com/releases/2008/10/081031112037.htm (accessed April 1, 2015).

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