Featured Research

from universities, journals, and other organizations

Antibiotic Use Increases At Academic Medical Centers

Date:
November 12, 2008
Source:
JAMA and Archives Journals
Summary:
Antibacterial drug use appears to have increased at academic medical centers between 2002 and 2006, driven primarily by greater use of broad-spectrum agents and the antibiotic vancomycin, according to a new article.

Antibacterial drug use appears to have increased at academic medical centers between 2002 and 2006, driven primarily by greater use of broad-spectrum agents and the antibiotic vancomycin, according to a new article.

Related Articles


Using antibacterial drugs increases the risk that pathogens will become resistant to their effects, according to background information in the article. Infection with drug-resistant bacteria is associated with greater illness and death and higher health care costs than infection with bacteria susceptible to antibiotics. "Many professional societies and national agencies have recommended monitoring antibacterial use and linking patterns of use to resistance," the authors write.

Amy L. Pakyz, Pharm.D., M.S., of Virginia Commonwealth University, Richmond, and colleagues measured antibiotic use documented in claims data from university teaching hospitals between 2002 and 2006. In 2006 and 2007, pharmacists or physicians specializing in infectious diseases at 19 hospitals completed a 12-question survey about factors that may influence antimicrobial drug use, including whether the hospital had a stewardship program to reduce antibiotic use.

Data were available from 35 hospitals in 2006—that year, a total of 775,731 patients were discharged, with 492,721 (63.5 percent) receiving an antibacterial drug. Between 2002 and 2006, the average total antibacterial use at the 22 hospitals providing five-year data increased from 798 days of therapy per every 1,000 days patients were in the hospital to 855 per 1,000 patient-days in 2006.

When antibiotic use was examined by class, fluoroquinolones were the most commonly used, and their use remained constant. Five broad-spectrum antibiotic classes—those that act against a wide range of bacteria—increased significantly, driving the overall increase. "The other change contributing to the increase in total use was the marked increase in the use of vancomycin," the authors write. "During five years, the mean [average] vancomycin use increased by 43 percent," and this drug became the single most commonly used antibacterial in the hospitals studied between 2004 and 2006.

"With few new antibacterials in development, antimicrobial stewardship programs in concert with aggressive infection control efforts represent the best chance for control of resistant pathogens," the authors write. "Stopping antibacterials when they are not needed, switching to more narrow-spectrum drug regimens and optimal dosing using pharmacokinetic and pharmacodynamic principles [interactions between drugs and the body] are critical. Equally important will be investigations designed to identify shorter durations of antibacterial treatments for nosocomial [hospital-acquired] infections that have the potential to dramatically decrease antibacterial exposure."

This study was funded in part by an investigator-initiated grant from Bayer.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amy L. Pakyz; Conan MacDougall; Michael Oinonen; Ronald E. Polk. Trends in Antibacterial Use in US Academic Health Centers: 2002 to 2006. Arch Intern Med., 2008;168(20):2254-2260 [link]

Cite This Page:

JAMA and Archives Journals. "Antibiotic Use Increases At Academic Medical Centers." ScienceDaily. ScienceDaily, 12 November 2008. <www.sciencedaily.com/releases/2008/11/081110163801.htm>.
JAMA and Archives Journals. (2008, November 12). Antibiotic Use Increases At Academic Medical Centers. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2008/11/081110163801.htm
JAMA and Archives Journals. "Antibiotic Use Increases At Academic Medical Centers." ScienceDaily. www.sciencedaily.com/releases/2008/11/081110163801.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins