Featured Research

from universities, journals, and other organizations

New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA

Date:
November 17, 2008
Source:
Rockefeller University Press
Summary:
Scientistst report the first in vivo experiments on the heterochromatin protein 1 family, which sidles up to silent DNA. The results, to be published in the Nov. 17 issue of the Journal of Cell Biology, add to the evidence that the different versions of the proteins help cells fix broken DNA.

Scientists report the first in vivo experiments on the heterochromatin protein 1 (HP1) family, which sidles up to silent DNA. The results, to be published in the Nov. 17 issue of the Journal of Cell Biology, add to the evidence that the different versions of the proteins help cells fix broken DNA.

The function of HP1 proteins has puzzled researchers. The proteins, which come in three forms in mammals, cozy up to heterochromatin—the tightly wound sections of DNA where genes are usually inactive. Early studies indicated that the proteins' job was to turn genes off. But recent work suggested that the proteins are essential for repairing damaged DNA. These results came from in vitro studies, however, and the proteins' powers in vivo remained uncertain.

Aucott et al. created the first mouse strain missing one of the HP1 versions, HP1b. The animals die shortly after birth because their lungs don't inflate. The rodents show brain defects as well. Large numbers of neurons die, for example, and the neural stem cells in the cortex divide sluggishly. Both effects could arise from unfixed DNA. When the researchers grew brain cells from HP1b-lacking mice in culture, they saw clear indications of genomic instability that can result from faulty DNA repair, including unpaired sister chromatids that separated prematurely and even extra sets of chromosomes. The HP1 proteins latch onto the methylated version of the H3 histone, but how this interaction promotes repair is an unanswered question.

Reference: Aucott, R., et al. 2008. J. Cell Biol. doi:10.1083/jcb.200804041.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA." ScienceDaily. ScienceDaily, 17 November 2008. <www.sciencedaily.com/releases/2008/11/081117091616.htm>.
Rockefeller University Press. (2008, November 17). New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/11/081117091616.htm
Rockefeller University Press. "New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA." ScienceDaily. www.sciencedaily.com/releases/2008/11/081117091616.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins