Featured Research

from universities, journals, and other organizations

New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA

Date:
November 17, 2008
Source:
Rockefeller University Press
Summary:
Scientistst report the first in vivo experiments on the heterochromatin protein 1 family, which sidles up to silent DNA. The results, to be published in the Nov. 17 issue of the Journal of Cell Biology, add to the evidence that the different versions of the proteins help cells fix broken DNA.

Scientists report the first in vivo experiments on the heterochromatin protein 1 (HP1) family, which sidles up to silent DNA. The results, to be published in the Nov. 17 issue of the Journal of Cell Biology, add to the evidence that the different versions of the proteins help cells fix broken DNA.

Related Articles


The function of HP1 proteins has puzzled researchers. The proteins, which come in three forms in mammals, cozy up to heterochromatin—the tightly wound sections of DNA where genes are usually inactive. Early studies indicated that the proteins' job was to turn genes off. But recent work suggested that the proteins are essential for repairing damaged DNA. These results came from in vitro studies, however, and the proteins' powers in vivo remained uncertain.

Aucott et al. created the first mouse strain missing one of the HP1 versions, HP1b. The animals die shortly after birth because their lungs don't inflate. The rodents show brain defects as well. Large numbers of neurons die, for example, and the neural stem cells in the cortex divide sluggishly. Both effects could arise from unfixed DNA. When the researchers grew brain cells from HP1b-lacking mice in culture, they saw clear indications of genomic instability that can result from faulty DNA repair, including unpaired sister chromatids that separated prematurely and even extra sets of chromosomes. The HP1 proteins latch onto the methylated version of the H3 histone, but how this interaction promotes repair is an unanswered question.

Reference: Aucott, R., et al. 2008. J. Cell Biol. doi:10.1083/jcb.200804041.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA." ScienceDaily. ScienceDaily, 17 November 2008. <www.sciencedaily.com/releases/2008/11/081117091616.htm>.
Rockefeller University Press. (2008, November 17). New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2008/11/081117091616.htm
Rockefeller University Press. "New Evidence On Different Versions Of Proteins Helping Cells Fix Broken DNA." ScienceDaily. www.sciencedaily.com/releases/2008/11/081117091616.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins