Featured Research

from universities, journals, and other organizations

Portuguese Scientists Discover New Mechanism That Regulates Formation Of Blood Vessels

Date:
November 30, 2008
Source:
Instituto Gulbenkian de Ciência (IGC)
Summary:
Researchers have discovered a novel mechanism which regulates the process whereby new blood vessels are formed and wounds heal, including chronic wounds, such as those found in diabetic patients and those suffering from morbid obesity. These findings have implications for the development of new therapeutic approaches to healing damaged blood vessels and building new ones.

Researchers in one of the external groups of the Instituto Gulbenkian de Ciência (IGC), in Portugal, have discovered a novel mechanism which regulates the process whereby new blood vessels are formed and wounds heal, including chronic wounds, such as those found in diabetic patients and those suffering from morbid obesity.

These findings, by Sérgio Dias and his team, are to appear in the new issue of the journal PLoSOne(*), and have implications for the development of new therapeutic approaches to healing damaged blood vessels and building new ones.

Working at the Centro de Investigação e Patobiologia Molecular of the Portuguese Institute of Oncology Francisco Gentil, in Lisbon, the team showed that the cells that make new blood vessels (called endothelial cells) are stimulated by an intracellular signalling pathway, mediated by the protein Notch.

The formation of new blood vessels is a crucial step in wound healing: the newly-formed vessels allow anti-inflammatory proteins to reach the wound site, improve oxygenation of the damaged tissue and carry essential nutrients for the re-structuring of the tissue, that is, the skin.

According to Francisco Caiado, a PhD student at the IGC, and first author of this study, “We knew that the endothelial cells are stimulated by cells originating in the bone-marrow, the so-called bone-marrow derived precursor cells. We have now shown that the actual stimulus happens through the Notch protein, found on the bone-marrow derived cells. Upon activation, Notch promotes the adhesion of the precursor cells to the site of the lesion, where they stimulate the endothelial cells to make new blood vessels”.

Chronic skin wounds are an increasing medical problem, since they are commonly found in diabetic patients and in those suffering from morbid obesity. Diabetic patients may develop “diabetic foot”, a condition whereby wounds do not heal leading, in the most severe cases, to amputation.


Story Source:

The above story is based on materials provided by Instituto Gulbenkian de Ciência (IGC). Note: Materials may be edited for content and length.


Journal Reference:

  1. Caiado et al. Notch Pathway Modulation on Bone Marrow-Derived Vascular Precursor Cells Regulates Their Angiogenic and Wound Healing Potential. PLoS ONE, 2008; 3 (11): e3752 DOI: 10.1371/journal.pone.0003752

Cite This Page:

Instituto Gulbenkian de Ciência (IGC). "Portuguese Scientists Discover New Mechanism That Regulates Formation Of Blood Vessels." ScienceDaily. ScienceDaily, 30 November 2008. <www.sciencedaily.com/releases/2008/11/081117153305.htm>.
Instituto Gulbenkian de Ciência (IGC). (2008, November 30). Portuguese Scientists Discover New Mechanism That Regulates Formation Of Blood Vessels. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/11/081117153305.htm
Instituto Gulbenkian de Ciência (IGC). "Portuguese Scientists Discover New Mechanism That Regulates Formation Of Blood Vessels." ScienceDaily. www.sciencedaily.com/releases/2008/11/081117153305.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins