Featured Research

from universities, journals, and other organizations

Neurons Derived From Embryonic Stem Cells Restore Muscle Function After Injury

Date:
November 20, 2008
Source:
Dalhousie University
Summary:
Researchers have discovered that embryonic stem cells may play a critical role in helping people with nerve damage and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), regain muscular strength.

Dalhousie Medical School researchers have discovered that embryonic stem cells may play a critical role in helping people with nerve damage and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), regain muscular strength.

Motor neurons reside in the spinal cord and control limb movements by enabling muscles to contract. Diseases like ALS cause them to degenerate, resulting in muscle weakness, atrophy, and eventual paralysis.

“This study builds on a series of studies in which we demonstrated that motor neurons can be generated from mouse embryonic stem cells,” says Dr. Victor Rafuse, associate professor of anatomy & neurobiology. “It’s very exciting that these neurons can be used for transplantation to prevent degeneration of muscle.”

The research team used embryonic stem cells from mice to grow motor neurons in the laboratory. They then transplanted the neurons into mouse nerves that were separated from the spinal cord. After separation, it would be expected that the nerves and muscles they control die. However, the Dalhousie group was the first in the world to find that the muscles not only were preserved by the transplantation, but they could produce about half their normal force to contract.

“This opens the door for a variety of different treatments,” says Dr. Rob Brownstone, professor of surgery and anatomy & neurobiology. “We’ve learned that muscles are preserved by stem cells; now we’re studying how this method can be applied to humans so that we can better treat people with nerve injuries and paralysis. Additionally, we’re looking at combining stem cell treatment with electrically-stimulated implants, which could stimulate nerves to produce movement.”

The study, which was also authored by graduate student Damien Yohn and former post-doctoral fellow Gareth Miles, was funded by New York-based Project A.L.S. It was published in today’s edition of Journal of Neuroscience.


Story Source:

The above story is based on materials provided by Dalhousie University. Note: Materials may be edited for content and length.


Cite This Page:

Dalhousie University. "Neurons Derived From Embryonic Stem Cells Restore Muscle Function After Injury." ScienceDaily. ScienceDaily, 20 November 2008. <www.sciencedaily.com/releases/2008/11/081119174716.htm>.
Dalhousie University. (2008, November 20). Neurons Derived From Embryonic Stem Cells Restore Muscle Function After Injury. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2008/11/081119174716.htm
Dalhousie University. "Neurons Derived From Embryonic Stem Cells Restore Muscle Function After Injury." ScienceDaily. www.sciencedaily.com/releases/2008/11/081119174716.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins