Featured Research

from universities, journals, and other organizations

Tumor Environment Determines Whether The Cellular Process Autophagy Enables Cancer Cells To Live Or Die

Date:
November 28, 2008
Source:
Journal of Clinical Investigation
Summary:
Confusingly, the cellular process autophagy (essentially self-eating) has been implicated in both cancer cell death and survival. New insight into this paradox has now been provided by work which indicates that the context in which the process occurs determines the outcome.

Confusingly, the cellular process autophagy (essentially self-eating) has been implicated in both cancer cell death and survival. New insight into this paradox has now been provided by the work of Robert Bast Jr. and colleagues, at the University of Texas MD Anderson Cancer Center, Houston, which indicates that the context in which the process occurs determines the outcome.

Related Articles


Expression of the gene ARHI is lost or downregulated in most cases of ovarian cancer. In the study, in vitro re-expression of ARHI in multiple human ovarian cancer cell lines induced autophagy and cell death.

However, when one of these cells lines was transplanted into mice as a xenograft, multiple factors within the tumor environment turned ARHI-induced autophagy into a mechanism of tumor cell survival, leading to tumor dormancy.

In addition to providing insight into the paradox that autophagy is associated with both cancer cell death and survival, the authors suggest that the data might provide new therapeutic approaches for the treatment of cancer.

Ravi Amaravadi, at the University of Pennsylvania, Philadelphia, discusses this further in an accompanying commentary.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Lu et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI35512
  2. Amaravadi et al. Autophagy-induced tumor dormancy in ovarian cancer. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37667

Cite This Page:

Journal of Clinical Investigation. "Tumor Environment Determines Whether The Cellular Process Autophagy Enables Cancer Cells To Live Or Die." ScienceDaily. ScienceDaily, 28 November 2008. <www.sciencedaily.com/releases/2008/11/081120173048.htm>.
Journal of Clinical Investigation. (2008, November 28). Tumor Environment Determines Whether The Cellular Process Autophagy Enables Cancer Cells To Live Or Die. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2008/11/081120173048.htm
Journal of Clinical Investigation. "Tumor Environment Determines Whether The Cellular Process Autophagy Enables Cancer Cells To Live Or Die." ScienceDaily. www.sciencedaily.com/releases/2008/11/081120173048.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins