Featured Research

from universities, journals, and other organizations

Vaccine And Drug Research Aimed At Ticks And Mosquitoes To Prevent Disease Transmission

Date:
December 11, 2008
Source:
American Society of Tropical Medicine and Hygiene
Summary:
Most successful vaccines and drugs rely on protecting humans or animals by blocking certain bacteria from growing in their systems. But a new theory actually hopes to take stopping infectious diseases such as West Nile virus and Malaria to the next level by disabling insects from transmitting these viruses.

Most successful vaccines and drugs rely on protecting humans or animals by blocking certain bacteria from growing in their systems. But, a new theory actually hopes to take stopping infectious diseases such as West Nile virus and Malaria to the next level by disabling insects from transmitting these viruses.

Related Articles


Research to be presented at the 57th American Society of Tropical Medicine and Hygiene (ASTMH) annual meeting in New Orleans, explains how vaccines and drugs may not only be able to stop disease transmission, but also prematurely kill the vectors carrying these diseases; such vectors include ticks, sand flies and mosquitoes – the insects responsible for most deaths world wide.

"In order to successfully slow the transmission rate of these potentially fatal diseases, we need to reduce the lifespan of the vector, or block them from becoming infected in the first place," explains Brian Foy, Ph.D., at Colorado State University. "One of our goals is to curtail the spread of mosquito-borne diseases through strategic use of compounds, known as endectocides, to target hosts. This new strategy will make blood meals from humans lethal to mosquitoes so they die before they can transmit a disease." Endectocides are currently mass administered to human populations to control the worm parasites that cause river blindness and are widely used in animals for worm control.

Professor Foy says that thanks to new technologies using genomics, scientists can now sift through vector genomes to more quickly and accurately find protein targets, which can then aid in the development of more specified drugs and vaccines.

A vaccine developed using functional genomics is already in early stages for cattle, whose production is greatly affected by tick-borne diseases. Katherine Kocan, Ph.D., at Oklahoma State University, concentrates her research on tick vaccines and anaplasmosis, a tick-transmitted disease of cattle that infects the red blood cells, causing mild to severe anemia and often death. "Even if the cow doesn't die," explains Professor Kocan, "the bacteria serve as a continued source of infection for cows and ticks. We are working on a vaccine to target tick-protective genes, so when ticks feed on immunized cattle, the vaccine antibodies interfere directly with the biology of the tick and its feeding pattern which results in reduced tick populations." The vaccine model being developed for cattle, which we call a dual target vaccine approach because both ticks and tick-borne pathogens are targeted, will likely be applicable to other ticks and the bacteria that they transmit.

According to Professor Foy, this theory of vaccine and drug development would offer many advantages over currently-used mosquito and tick-borne disease control measures: it would be more targeted than environmental spraying of insecticides; proper application would kill older frequently-biting insects and interrupt disease transmission; resistance would be slower to develop; and there may be little cross-resistance from agricultural applications.


Story Source:

The above story is based on materials provided by American Society of Tropical Medicine and Hygiene. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Tropical Medicine and Hygiene. "Vaccine And Drug Research Aimed At Ticks And Mosquitoes To Prevent Disease Transmission." ScienceDaily. ScienceDaily, 11 December 2008. <www.sciencedaily.com/releases/2008/12/081202170822.htm>.
American Society of Tropical Medicine and Hygiene. (2008, December 11). Vaccine And Drug Research Aimed At Ticks And Mosquitoes To Prevent Disease Transmission. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2008/12/081202170822.htm
American Society of Tropical Medicine and Hygiene. "Vaccine And Drug Research Aimed At Ticks And Mosquitoes To Prevent Disease Transmission." ScienceDaily. www.sciencedaily.com/releases/2008/12/081202170822.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins