Featured Research

from universities, journals, and other organizations

Eye Disorders Linked To Statin Drug Use In Some Patients

Date:
December 10, 2008
Source:
American Academy of Ophthalmology
Summary:
Statin medications are used to lower patients' cholesterol levels, thus helping prevent coronary heart disease, stroke and other deaths related to high cholesterol levels. Statin use has grown rapidly since 1992, and seems likely to increase in light of the recent, widely-reported Jupiter Study on statin benefits in patients with low cholesterol but elevated C-reactive protein.

Statin medications are used to lower patients' cholesterol levels, thus helping prevent coronary heart disease, stroke and other deaths related to high cholesterol levels. Statin use has grown rapidly since 1992, and seems likely to increase in light of the recent, widely-reported Jupiter Study on statin benefits in patients with low cholesterol but elevated C-reactive protein. Eye disorders related to statins are rare, occurring in about 0.1 percent of patients (0.5 to 2.5 percent when gemfibrozil, another type of cholesterol-lowering drug, is taken simultaneously).

A new study led by F.W. Fraunfelder, MD, of the Casey Eye Institute, Oregon Health & Science University, is the first to systematically report on the association of eye disorders with statin use. The study appears in the Dec. 1 issue of Ophthalmology, the journal of the American Academy of Ophthalmology.

Dr. Fraunfelder's group analyzed statin-associated reports of double vision (diplopia), drooping of the upper eyelid (ptosis), and loss of full range of motion of the eyes (ophthalmoplegia) in the databases of the National Registry of Drug-Induced Ocular Side Effects, the World Health Organization, and the Food and Drug Administration. Since statins were known to cause skeletal muscle disorders in some patients, a similar affect was plausible in the eye muscles.

The average patient age was 64.5 years, and the case reports included 143 males, 91 females, and 22 persons with gender unspecified. The average statin dose of patients who exhibited one or more eye disorder was within ranges recommended by drug manufacturers, and the average time from beginning of therapy to developing an adverse drug reaction (ADR) was 8.3 months. There were 23 cases of loss of eye range of motion, 8 cases of ptosis, and 18 cases of ptosis in conjunction with double vision; disorders in all patients apparently resolved completely when statins were discontinued.

From the ADR reports, the researchers could not determine precisely which eye muscles were involved, or time needed to full recovery after statin discontinuation, for individual cases.

"We advise physicians prescribing statins to be aware that these eye disorders may result, and that medications should be discontinued if so. When a patient has one of these eye disorders, he should be rigorously evaluated to determine the cause, and statin use should be taken into account," Dr. Fraunfelder concludes.


Story Source:

The above story is based on materials provided by American Academy of Ophthalmology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Ophthalmology. "Eye Disorders Linked To Statin Drug Use In Some Patients." ScienceDaily. ScienceDaily, 10 December 2008. <www.sciencedaily.com/releases/2008/12/081202182232.htm>.
American Academy of Ophthalmology. (2008, December 10). Eye Disorders Linked To Statin Drug Use In Some Patients. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2008/12/081202182232.htm
American Academy of Ophthalmology. "Eye Disorders Linked To Statin Drug Use In Some Patients." ScienceDaily. www.sciencedaily.com/releases/2008/12/081202182232.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins