Featured Research

from universities, journals, and other organizations

Eye Disorders Linked To Statin Drug Use In Some Patients

Date:
December 10, 2008
Source:
American Academy of Ophthalmology
Summary:
Statin medications are used to lower patients' cholesterol levels, thus helping prevent coronary heart disease, stroke and other deaths related to high cholesterol levels. Statin use has grown rapidly since 1992, and seems likely to increase in light of the recent, widely-reported Jupiter Study on statin benefits in patients with low cholesterol but elevated C-reactive protein.

Statin medications are used to lower patients' cholesterol levels, thus helping prevent coronary heart disease, stroke and other deaths related to high cholesterol levels. Statin use has grown rapidly since 1992, and seems likely to increase in light of the recent, widely-reported Jupiter Study on statin benefits in patients with low cholesterol but elevated C-reactive protein. Eye disorders related to statins are rare, occurring in about 0.1 percent of patients (0.5 to 2.5 percent when gemfibrozil, another type of cholesterol-lowering drug, is taken simultaneously).

A new study led by F.W. Fraunfelder, MD, of the Casey Eye Institute, Oregon Health & Science University, is the first to systematically report on the association of eye disorders with statin use. The study appears in the Dec. 1 issue of Ophthalmology, the journal of the American Academy of Ophthalmology.

Dr. Fraunfelder's group analyzed statin-associated reports of double vision (diplopia), drooping of the upper eyelid (ptosis), and loss of full range of motion of the eyes (ophthalmoplegia) in the databases of the National Registry of Drug-Induced Ocular Side Effects, the World Health Organization, and the Food and Drug Administration. Since statins were known to cause skeletal muscle disorders in some patients, a similar affect was plausible in the eye muscles.

The average patient age was 64.5 years, and the case reports included 143 males, 91 females, and 22 persons with gender unspecified. The average statin dose of patients who exhibited one or more eye disorder was within ranges recommended by drug manufacturers, and the average time from beginning of therapy to developing an adverse drug reaction (ADR) was 8.3 months. There were 23 cases of loss of eye range of motion, 8 cases of ptosis, and 18 cases of ptosis in conjunction with double vision; disorders in all patients apparently resolved completely when statins were discontinued.

From the ADR reports, the researchers could not determine precisely which eye muscles were involved, or time needed to full recovery after statin discontinuation, for individual cases.

"We advise physicians prescribing statins to be aware that these eye disorders may result, and that medications should be discontinued if so. When a patient has one of these eye disorders, he should be rigorously evaluated to determine the cause, and statin use should be taken into account," Dr. Fraunfelder concludes.


Story Source:

The above story is based on materials provided by American Academy of Ophthalmology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Ophthalmology. "Eye Disorders Linked To Statin Drug Use In Some Patients." ScienceDaily. ScienceDaily, 10 December 2008. <www.sciencedaily.com/releases/2008/12/081202182232.htm>.
American Academy of Ophthalmology. (2008, December 10). Eye Disorders Linked To Statin Drug Use In Some Patients. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/12/081202182232.htm
American Academy of Ophthalmology. "Eye Disorders Linked To Statin Drug Use In Some Patients." ScienceDaily. www.sciencedaily.com/releases/2008/12/081202182232.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins