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Better Antifreezes To Preserve Donor Organs For Transplantation

Date:
December 31, 2008
Source:
American Chemical Society
Summary:
Chemists in Canada have developed a new approach for producing more effective medical antifreeze fluids for preserving kidneys, hearts, and other organs donated for transplantation. These next-generation antifreezes can decrease damage to organs caused by ice crystals, and thus prolong the time a donated organ will remain viable prior to transplantation. This could increase the number of available organs for potential recipients.

Chemists have developed a method to better preserve organs for transplantation.
Credit: American Chemical Society

Chemists in Canada have developed a new approach for producing more effective medical antifreeze fluids for preserving kidneys, hearts, and other organs donated for transplantation. These next-generation antifreezes can decrease damage to organs caused by ice crystals, and thus prolong the time a donated organ will remain viable prior to transplantation. This could increase the number of available organs for potential recipients.

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Robert N. Ben and colleagues note that the growth of ice crystals is a major cause of damage to cells, tissues and organs during cryopreservation, which leaves them unusable for transplantation. To address this challenge, the researchers developed synthetic antifreeze materials, called C-linked antifreeze glycoprotein analogues (C-AFGP). These proteins contain a sugar coating and have custom-tailored antifreeze activity.

Now the scientists describe the development of "hydration index" that can be used to more reliably predict how prospective antifreeze materials will behave. Their index provides a clearer picture of how water molecules interact with the sugar component (as well as native AFGP) and affect their chemical behavior. This is a key to understanding their ability to resist the formation of ice crystals when chilled.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tam et al. Hydration IndexA Better Parameter for Explaining Small Molecule Hydration in Inhibition of Ice Recrystallization. Journal of the American Chemical Society, 2008; 130 (51): 17494 DOI: 10.1021/ja806284x

Cite This Page:

American Chemical Society. "Better Antifreezes To Preserve Donor Organs For Transplantation." ScienceDaily. ScienceDaily, 31 December 2008. <www.sciencedaily.com/releases/2008/12/081222081214.htm>.
American Chemical Society. (2008, December 31). Better Antifreezes To Preserve Donor Organs For Transplantation. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2008/12/081222081214.htm
American Chemical Society. "Better Antifreezes To Preserve Donor Organs For Transplantation." ScienceDaily. www.sciencedaily.com/releases/2008/12/081222081214.htm (accessed February 28, 2015).

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