Featured Research

from universities, journals, and other organizations

Prognostic Test for Breast Cancer May Not Detect All Tumor Types

Date:
January 8, 2009
Source:
Journal of the National Cancer Institute
Summary:
An antibody-based test that is used to detect circulating breast cancer cells and provide prognostic information for patients during treatment may not detect all subtypes of breast cancer.

An antibody-based test that is used to detect circulating breast cancer cells and provide prognostic information for patients during treatment may not detect all subtypes of breast cancer.

Related Articles


Researchers have identified five subtypes of breast cancer by their gene expression patterns. The subtypes – basal, HER2-positive, luminal A and B, and normal-like – vary in their natural history and response to therapy. CellSearch is an antibody-based test, approved by the U.S. Food and Drug Administration, to detect circulating breast cancer cells in patients before and during treatment. Previous studies suggest that women who have a decrease in circulating tumor cells after the start of treatment are likely to have a better outcome than those who do not have a decline. It was not known if the CellSearch assay detected all five subtypes of cancer equally.

In the current study, Anieta Sieuwerts, Ph.D., of the Erasmus Medical Center in Rotterdam, The Netherlands, and colleagues tested whether the assay could isolate cells of breast cancer cell lines whose subtype is known that had been added to human blood from a healthy volunteer. The investigators tested cells from a total of 34 cell lines that represented a mix of the five breast cancer subtypes.

The assay did not detect the nine normal-like breast cancer cells but did detect the other subtypes. "New tests that include antibodies that specifically recognize normal-like breast tumor cells…are needed," the authors conclude.

This research is published in the December 30 issue of the Journal of the National Cancer Institute.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Prognostic Test for Breast Cancer May Not Detect All Tumor Types." ScienceDaily. ScienceDaily, 8 January 2009. <www.sciencedaily.com/releases/2008/12/081231005347.htm>.
Journal of the National Cancer Institute. (2009, January 8). Prognostic Test for Breast Cancer May Not Detect All Tumor Types. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2008/12/081231005347.htm
Journal of the National Cancer Institute. "Prognostic Test for Breast Cancer May Not Detect All Tumor Types." ScienceDaily. www.sciencedaily.com/releases/2008/12/081231005347.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins