Featured Research

from universities, journals, and other organizations

Substance Use Common Among Patients With TB, Associated With Treatment Difficulties

Date:
January 28, 2009
Source:
JAMA and Archives Journals
Summary:
About one in five US tuberculosis patients reports abusing alcohol or using illicit drugs, and those who do appear more contagious and difficult to treat, according to a new report.

About one in five U.S. tuberculosis patients reports abusing alcohol or using illicit drugs, and those who do appear more contagious and difficult to treat, according to a new report.

Related Articles


The annual rate of new tuberculosis (TB) cases in the United States is among the lowest in the world, according to background information in the article. However, certain groups remain at higher risk. "The epidemiology of TB in the United States has been best summarized by Iseman: 'As the epidemic tide of tuberculosis recedes from the shores of America, small tidepools of disease remain behind: pools populated by immigrants, the elderly and the immunocompromised'," the authors write. "A less frequently discussed tidepool that complicates U.S. TB control efforts is the illicit drug–using and alcohol-abusing population."

John E. Oeltmann, Ph.D., of the Centers for Disease Control and Prevention, Atlanta, and colleagues analyzed data from 153,268 patients 15 years or older who were reported to have TB between 1997 and 2006. Of these, 28,650 (18.7 percent) reported substance abuse—a larger percentage than those who reported any other established risk factors for TB, including recent immigration to the United States (12.9 percent), infection with HIV (9.5 percent), living in a group setting (6.6 percent), homelessness (6.3 percent) or working in a high-risk occupation (4.3 percent).

"Our results suggest that substance abuse is the most commonly reported modifiable behavior impeding TB elimination efforts in the United States," the authors write. Among patients who were negative for HIV, those who reported substance abuse were 1.8 times more likely to have a more contagious form of TB (as indicated by a positive sputum smear). Females who were substance abusers were 2.4 times more likely to experience treatment failure than were other females.

"The relation between substance abuse and increased transmission of Mycobacterium tuberculosis can be explained in several ways, some of which are indirect and revolve around delayed diagnosis and difficulties identifying at-risk contacts, screening them for TB and treating patients with positive findings," the authors write. "Persons who abuse substances may have less access to routine medical care, potentially leading to delayed diagnoses. As the disease progresses, patients tend to become more contagious."

Patients who abuse substances are less likely to be screened for TB or to begin and complete treatment for latent infection or active disease, the authors note—problems compounded by the compromised immune systems of individuals who abuse alcohol, crack cocaine, heroin, marijuana and methamphetamines. In addition, antituberculosis medications are usually metabolized by the liver, which is often damaged by substance abuse.

"Tuberculosis control and substance abuse programs need to work together to simultaneously treat the diseases of addiction and TB," the authors conclude.

This study was funded by the Centers for Disease Control and Prevention, Division of Tuberculosis Elimination.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Oeltmann et al. Tuberculosis and Substance Abuse in the United States, 1997-2006. Archives of Internal Medicine, 2009; 169 (2): 189 DOI: 10.1001/archinternmed.2008.535

Cite This Page:

JAMA and Archives Journals. "Substance Use Common Among Patients With TB, Associated With Treatment Difficulties." ScienceDaily. ScienceDaily, 28 January 2009. <www.sciencedaily.com/releases/2009/01/090126173619.htm>.
JAMA and Archives Journals. (2009, January 28). Substance Use Common Among Patients With TB, Associated With Treatment Difficulties. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2009/01/090126173619.htm
JAMA and Archives Journals. "Substance Use Common Among Patients With TB, Associated With Treatment Difficulties." ScienceDaily. www.sciencedaily.com/releases/2009/01/090126173619.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins