Featured Research

from universities, journals, and other organizations

Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses

Date:
January 28, 2009
Source:
University of Montreal
Summary:
Scientists have discovered a process to produce new metal surfaces that promise to lead to superior medical implants that will improve healing and allow the human body to better accept metal prostheses.

The futuristic technology of the Six Million Dollar Man –specifically a part metal and part flesh human being – won't be exclusive to Hollywood anymore. While the main character in the Six Million Dollar Man was outfitted with metals to enhance his performance, a multidisciplinary team of scientists led by the Université de Montréal has discovered a process to produce new metal surfaces that promise to lead to superior medical implants that will improve healing and allow the human body to better accept metal prostheses.

According to new research published in Nano Letters, the scientists capitalized on recent advances in nanotechnology to change how metals can influence cell growth and development in the body. A critical aspect of the finding is that the surfaces can directly stimulate cells – thereby eliminating the need for pharmaceuticals and resulting side-effects.

The study is a collaboration between the Université de Montréal, McGill University, the Institut National de la Recherche Scientifique (INRS-EMT), Plasmionique Inc and the Universidade de São Paulo.

"Using chemical modification, we have produced metals with intelligent surfaces that positively interact with cells and help control the biological healing response," says Antonio Nanci, the study's senior author and a professor at the Université de Montréal's Faculty of Dentistry. "These will be the building-blocks of new and improved metal implants that are expected to significantly affect the success of orthopedic, dental and cardiovascular prostheses."

Etching produces nanoporous surfaces

Dr. Nanci and colleagues applied chemical compounds to modify the surface of the common biomedical metals such as titanium. Exposing these metals to selected etching mixtures of acids and oxidants results in surfaces with a sponge-like pattern of nano (ultra small) pits. "We demonstrated that some cells stick better to these surfaces than they do to the traditional smooth ones," says Dr. Nanci. "This is already an improvement to the standard available biomaterial."

The researchers then tested the effects of the chemically-produced nanoporous titanium surfaces on cell growth and development. They showed that the treated surfaces increased growth of bone cells, decreased growth of unwanted cells and stimulated stem cells, relative to untreated smooth ones. In addition, expression of genes required for cell adhesion and growth were increased in contact with the nanoporous surfaces.

Different etchants have different effects

Uncontrolled growth of cells on an implant is not ideal. For example, when using cardiovascular stents, it is important to limit the growth of certain cells in order not interfere with blood flow. Also, in some cases, cells can form an undesirable capsule around dental implants causing them to fall. The scientists demonstrated that treatment with specific etchants reduced the growth of unwanted cells.

"An important element of this study is how we demonstrated the selective cellular effects of etching," says Dr. Nanci. "With subtle changes in chemical composition of etching mixtures, we can alter the nanopatterns that are created on the metal surface and control consequent cellular responses."

"Our study is groundbreaking," adds Dr. Nanci. "We use simple yet very efficient chemical treatments to alter metals commonly used in the operating room. This innovative approach may ultimately hold the key to developing intelligent materials that are not only easily accepted by the human body but that can actively respond to the surrounding biological environment."

This study was funded by the Canadian Institutes of Health Research, the Natural Science and Engineering Research Council of Canada, the Canada Foundation for Innovation, the Fonds québécois de la recherche sur la nature et les technologies, the São Paulo State Research Foundation and the Canadian Bureau for International Education.

 


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vetrone et al. Nanoscale Oxidative Patterning of Metallic Surfaces to Modulate Cell Activity and Fate. Nano Letters, 2009: 090121163055083 DOI: 10.1021/nl803051f

Cite This Page:

University of Montreal. "Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses." ScienceDaily. ScienceDaily, 28 January 2009. <www.sciencedaily.com/releases/2009/01/090127123002.htm>.
University of Montreal. (2009, January 28). Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2009/01/090127123002.htm
University of Montreal. "Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses." ScienceDaily. www.sciencedaily.com/releases/2009/01/090127123002.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins