Featured Research

from universities, journals, and other organizations

Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses

Date:
January 28, 2009
Source:
University of Montreal
Summary:
Scientists have discovered a process to produce new metal surfaces that promise to lead to superior medical implants that will improve healing and allow the human body to better accept metal prostheses.

The futuristic technology of the Six Million Dollar Man –specifically a part metal and part flesh human being – won't be exclusive to Hollywood anymore. While the main character in the Six Million Dollar Man was outfitted with metals to enhance his performance, a multidisciplinary team of scientists led by the Université de Montréal has discovered a process to produce new metal surfaces that promise to lead to superior medical implants that will improve healing and allow the human body to better accept metal prostheses.

Related Articles


According to new research published in Nano Letters, the scientists capitalized on recent advances in nanotechnology to change how metals can influence cell growth and development in the body. A critical aspect of the finding is that the surfaces can directly stimulate cells – thereby eliminating the need for pharmaceuticals and resulting side-effects.

The study is a collaboration between the Université de Montréal, McGill University, the Institut National de la Recherche Scientifique (INRS-EMT), Plasmionique Inc and the Universidade de São Paulo.

"Using chemical modification, we have produced metals with intelligent surfaces that positively interact with cells and help control the biological healing response," says Antonio Nanci, the study's senior author and a professor at the Université de Montréal's Faculty of Dentistry. "These will be the building-blocks of new and improved metal implants that are expected to significantly affect the success of orthopedic, dental and cardiovascular prostheses."

Etching produces nanoporous surfaces

Dr. Nanci and colleagues applied chemical compounds to modify the surface of the common biomedical metals such as titanium. Exposing these metals to selected etching mixtures of acids and oxidants results in surfaces with a sponge-like pattern of nano (ultra small) pits. "We demonstrated that some cells stick better to these surfaces than they do to the traditional smooth ones," says Dr. Nanci. "This is already an improvement to the standard available biomaterial."

The researchers then tested the effects of the chemically-produced nanoporous titanium surfaces on cell growth and development. They showed that the treated surfaces increased growth of bone cells, decreased growth of unwanted cells and stimulated stem cells, relative to untreated smooth ones. In addition, expression of genes required for cell adhesion and growth were increased in contact with the nanoporous surfaces.

Different etchants have different effects

Uncontrolled growth of cells on an implant is not ideal. For example, when using cardiovascular stents, it is important to limit the growth of certain cells in order not interfere with blood flow. Also, in some cases, cells can form an undesirable capsule around dental implants causing them to fall. The scientists demonstrated that treatment with specific etchants reduced the growth of unwanted cells.

"An important element of this study is how we demonstrated the selective cellular effects of etching," says Dr. Nanci. "With subtle changes in chemical composition of etching mixtures, we can alter the nanopatterns that are created on the metal surface and control consequent cellular responses."

"Our study is groundbreaking," adds Dr. Nanci. "We use simple yet very efficient chemical treatments to alter metals commonly used in the operating room. This innovative approach may ultimately hold the key to developing intelligent materials that are not only easily accepted by the human body but that can actively respond to the surrounding biological environment."

This study was funded by the Canadian Institutes of Health Research, the Natural Science and Engineering Research Council of Canada, the Canada Foundation for Innovation, the Fonds québécois de la recherche sur la nature et les technologies, the São Paulo State Research Foundation and the Canadian Bureau for International Education.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vetrone et al. Nanoscale Oxidative Patterning of Metallic Surfaces to Modulate Cell Activity and Fate. Nano Letters, 2009: 090121163055083 DOI: 10.1021/nl803051f

Cite This Page:

University of Montreal. "Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses." ScienceDaily. ScienceDaily, 28 January 2009. <www.sciencedaily.com/releases/2009/01/090127123002.htm>.
University of Montreal. (2009, January 28). Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2009/01/090127123002.htm
University of Montreal. "Nanotechnology Provides New Generation Of Orthopedic, Dental And Cardiovascular Prostheses." ScienceDaily. www.sciencedaily.com/releases/2009/01/090127123002.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) — NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) — A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) — Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) — The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins