Featured Research

from universities, journals, and other organizations

Gene Variants Affecting Blood Fats Identified

Date:
February 5, 2009
Source:
USDA/Agricultural Research Service
Summary:
Scientists have identified new genetic sites harboring common variations in DNA that are linked to imbalances in concentrations of blood lipids (fats). The findings provide another step forward in understanding the genetic contribution to dyslipidemia, a condition marked by overproduction of low-density lipoprotein (LDL "bad" cholesterol) and triglycerides, and underproduction of high-density lipoprotein (HDL "good"cholesterol).

A team of researchers has identified new genetic sites harboring common variations in DNA that are linked to imbalances in concentrations of blood lipids (fats). The findings provide another step forward in understanding the genetic contribution to dyslipidemia, a condition marked by overproduction of low-density lipoprotein (LDL "bad" cholesterol) and triglycerides, and underproduction of high-density lipoprotein (HDL "good"cholesterol).

The extensive research team included senior author and nutrigenomics expert Jose Ordovas of the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University in Boston, Mass. The HNRCA is funded by the Agricultural Research Service (ARS), a scientific research agency of the U.S. Department of Agriculture. The study was headed by Boston-based Massachusetts General Hospital physician Sekar Kathiresan.

For the first stage of the study, the researchers analyzed data from seven "genome-wide association" studies. Together, these studies provided more than 2.6 million DNA markers, called single nucleotide polymorphisms, or SNPs, from 19,840 individuals. These SNPs were then tested for associations with lipoprotein traits.

The data from the first stage of the study confirmed previously reported findings: Variants among eight earlier identified SNPs once again were associated with lipid levels. The Stage One analysis also uncovered 25 other DNA areas, or loci, of interest.

For the second stage of the study, the researchers genotyped SNPs in 20,623 individuals from five other studies, and looked further into the 25 promising loci.

In a combined analysis of stages one and two, SNPs at 30 loci were convincingly associated with all three blood lipids. These include a total of 19 previously identified loci confirmed in stage one, and 11 newly identified loci associated with lipids.

While each of the 30 loci conferred a modest effect individually, the analysis suggests that the more lipid-risk variants found in one individual, the higher his or her association with dyslipidemia. Together, the 30 sites explain a significant percentage of the genetic contribution to lipid levels among individuals. More DNA sequence variants could be identified with larger samples and improved statistical power for gene discovery, according to authors.


Story Source:

The above story is based on materials provided by USDA/Agricultural Research Service. Note: Materials may be edited for content and length.


Cite This Page:

USDA/Agricultural Research Service. "Gene Variants Affecting Blood Fats Identified." ScienceDaily. ScienceDaily, 5 February 2009. <www.sciencedaily.com/releases/2009/01/090131123204.htm>.
USDA/Agricultural Research Service. (2009, February 5). Gene Variants Affecting Blood Fats Identified. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/01/090131123204.htm
USDA/Agricultural Research Service. "Gene Variants Affecting Blood Fats Identified." ScienceDaily. www.sciencedaily.com/releases/2009/01/090131123204.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins