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Inflammation May Be Link Between Extreme Sleep Durations And Poor Health

Date:
February 7, 2009
Source:
American Academy of Sleep Medicine
Summary:
Sleep duration is associated with changes in the levels of specific cytokines that are important in regulating inflammation. The results suggest that inflammation may be the pathway linking extreme sleep durations to an increased risk for disease.

A new study in the journal Sleep shows that sleep duration is associated with changes in the levels of specific cytokines that are important in regulating inflammation. The results suggest that inflammation may be the pathway linking extreme sleep durations to an increased risk for disease.

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Each additional hour of self-reported sleep duration was associated with an eight-percent increase in C-reactive protein (CRP) levels and a seven-percent increase in interleukin-6 (IL-6), which are two inflammatory mediators. In contrast, each hour of reduction in sleep measured objectively by polysomnography was associated with an eight-percent increase in tumor necrosis factor alpha, another pro-inflammatory cytokine.

"The most surprising finding was that we found different relationships based on how sleep was measured," said lead author Dr. Sanjay R. Patel, assistant professor of medicine at Case Western Reserve University in Cleveland, Ohio.

According to the authors, research has linked both short and long sleep durations with an increased risk for mortality, coronary heart disease, diabetes and obesity. Chronic elevations in cytokines such as CRP and IL-6 also are associated with an increased risk of problems such as diabetes and heart disease.

The study involved 614 individuals from the Cleveland Family Study, a longitudinal family-based epidemiological cohort designed to study the genetics of obstructive sleep apnea (OSA). Participants completed questionnaires about sleep habits and underwent one night of polysomnography. In the morning a fasting blood sample was collected, and it was analyzed for five inflammatory cytokines.

Mean self-reported habitual sleep duration was 7.6 hours; mean sleep duration measured by polysomnography on the night prior to blood sampling was 6.2 hours. Those with long sleep durations, assessed by either measure, were significantly younger. Short sleep duration measured by polysomnography was associated with an increased prevalence of diabetes, hypertension and obstructive sleep apnea.

According to the authors the differing patterns of association with cytokine levels suggest that self-reported habitual sleep duration may measure chronic sleep exposure, while polysomnography may measure an acute exposure. They also note that the two methods of measuring sleep duration may be influenced differently by an underlying predictor of sleep habits such as stress or mood, which may have a direct effect on cytokine levels.


Story Source:

The above story is based on materials provided by American Academy of Sleep Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sleep Duration and Biomarkers of Inflammation. Sleep, Feb 1, 2009

Cite This Page:

American Academy of Sleep Medicine. "Inflammation May Be Link Between Extreme Sleep Durations And Poor Health." ScienceDaily. ScienceDaily, 7 February 2009. <www.sciencedaily.com/releases/2009/02/090201094119.htm>.
American Academy of Sleep Medicine. (2009, February 7). Inflammation May Be Link Between Extreme Sleep Durations And Poor Health. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/02/090201094119.htm
American Academy of Sleep Medicine. "Inflammation May Be Link Between Extreme Sleep Durations And Poor Health." ScienceDaily. www.sciencedaily.com/releases/2009/02/090201094119.htm (accessed March 29, 2015).

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