Featured Research

from universities, journals, and other organizations

Advancement In Tissue Engineering Promotes Oral Wound Healing

Date:
February 8, 2009
Source:
Cell Transplantation
Summary:
A Netherlands-based research team has successfully engineered a full-thickness gum tissue substitute from patient-donated biopsied tissue for use in reconstructing the oral cavity following surgery or trauma. Patient self-donated tissue was cultured and expanded in vitro for three weeks before transplantation. The advancement is a significant improvement over other skin substitutes as results demonstrate the importance of matching the donor site with the area to be transplanted.

Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) substitute that can be used for reconstruction in the oral cavity.

Related Articles


Their work was reported in the current issue of Cell Transplantation (17:10/11).

According to the study's lead author, Dr. Susan Gibbs of the VU University Medical Centre in Amsterdam, skin substitutes have been far more advanced than oral gingiva substitutes and, until now, no oral tissue-engineered products have been available for clinical applications. The team was the first to develop an autologous (same patient) full thickness skin substitute that Dr. Gibbs says is "proving to be very successful." However, they wanted to develop an autologous, full thickness oral substitute with the correct oral characteristics.

"Reconstructive surgery within the oral cavity is required during tumor excision, cleft palate repair, trauma, repair of diseased tissue and for generating soft tissue around teeth and dental implants," explained Dr. Gibbs. "Drawbacks of using skin as an autograft material in the oral cavity include bulkiness, sweating and hair formation and the limited amount of donor tissue available."

Their current study was aimed at constructing analogous, full-thickness oral substitutes in a similar manner to their skin substitute while maintaining the needed characteristics for successful oral transplantation. They used small amounts of patient oral tissue obtained from biopsies, then cultured and expanded the tissues in vitro over a three-week period.

Results of their study with a small number of patients showed that the gingiva substitute was "promising" and supported the need to carry out a larger patient study in the future.

"This study emphasized the importance of closely matching the donor site with the area to be transplanted," said Dr. Gibbs. "Our results represent a large step forward in the area of clinical applications in oral tissue engineering which, until now, have lagged behind skin tissue engineering."

"The reported study provides great encouragement in the clinical setting, for the ability to repair gingivitis and other gum diseases that affect a large number of people" said Dr. Amit Patel, a section editor of the journal Cell Transplantation.


Story Source:

The above story is based on materials provided by Cell Transplantation. Note: Materials may be edited for content and length.


Cite This Page:

Cell Transplantation. "Advancement In Tissue Engineering Promotes Oral Wound Healing." ScienceDaily. ScienceDaily, 8 February 2009. <www.sciencedaily.com/releases/2009/02/090203080725.htm>.
Cell Transplantation. (2009, February 8). Advancement In Tissue Engineering Promotes Oral Wound Healing. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2009/02/090203080725.htm
Cell Transplantation. "Advancement In Tissue Engineering Promotes Oral Wound Healing." ScienceDaily. www.sciencedaily.com/releases/2009/02/090203080725.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins