Featured Research

from universities, journals, and other organizations

Deciphering The Body's Healing Secrets

Date:
February 16, 2009
Source:
Centenary Institute
Summary:
Healthy blood vessels play a key role in the prevention and treatment of diseases such as cardiovascular disease and diabetes. Endothelial cells line the blood vessels and are critical to the regulation of blood vessel growth and function. Researchers at the Centenary Institute have discovered a mechanism that helps control the development of endothelial cells.

Healthy blood vessels play a key role in the prevention and treatment of diseases such as cardiovascular disease and diabetes.

Endothelial cells line the blood vessels and are critical to the regulation of blood vessel growth and function.

Researchers at the Centenary Institute have discovered a mechanism that helps control the development of endothelial cells.

Professor Jenny Gamble, Head of the Vascular Biology program at Centenary, says the process by which endothelial progenitor cells (EPCs) change to mature endothelial cells is an important but little understood control.

"If endothelial cell lining is injured or damaged, for example during wound healing, an organ transplant or heart attack, the EPC leave the bone marrow, circulate in the blood and home to the site of the injury where they continue to repair and are induced to become mature cells," she explains.

Publishing in Blood, Professor Gamble and her team found that this process, called differentiation, is partly controlled by the enzyme sphingosine kinase-1.

"We found that high levels of SK-1 keep the cells as EPCs whereas a decrease in the amount of SK-1 allows the cell to differentiate to functionally mature endothelial cells."

By understanding these fundamental tools the body uses to heal itself, there is potential to manipulate this process to create new treatments.

For example, the vascular complications of diabetes are attributed, in part, to the decreased numbers and function of EPCs. Additionally, stents are used extensively for the treatment of cardiovascular disease. However they can often be problematic because of a lack of good endothelial cell coverage.

Centenary Institute Executive Director, Professor Mathew Vadas says an increased understanding of the process of differentiation may allow SK-1 to be manipulated to drive this process and therefore improve treatments of these diseases in the future.

Publication reference

Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Proia RL, Vadas MA, Gamble JR.Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood. 2008 Dec 24. [Epub ahead of print].


Story Source:

The above story is based on materials provided by Centenary Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. S. Bonder, W. Y. Sun, T. Matthews, C. Cassano, X. Li, H. S. Ramshaw, S. M. Pitson, A. F. Lopez, P. T. Coates, R. L. Proia, M. A. Vadas, and J. R. Gamble. Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 2009; 113 (8) [link]

Cite This Page:

Centenary Institute. "Deciphering The Body's Healing Secrets." ScienceDaily. ScienceDaily, 16 February 2009. <www.sciencedaily.com/releases/2009/02/090212093710.htm>.
Centenary Institute. (2009, February 16). Deciphering The Body's Healing Secrets. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/02/090212093710.htm
Centenary Institute. "Deciphering The Body's Healing Secrets." ScienceDaily. www.sciencedaily.com/releases/2009/02/090212093710.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins