Featured Research

from universities, journals, and other organizations

Deciphering The Body's Healing Secrets

Date:
February 16, 2009
Source:
Centenary Institute
Summary:
Healthy blood vessels play a key role in the prevention and treatment of diseases such as cardiovascular disease and diabetes. Endothelial cells line the blood vessels and are critical to the regulation of blood vessel growth and function. Researchers at the Centenary Institute have discovered a mechanism that helps control the development of endothelial cells.

Healthy blood vessels play a key role in the prevention and treatment of diseases such as cardiovascular disease and diabetes.

Endothelial cells line the blood vessels and are critical to the regulation of blood vessel growth and function.

Researchers at the Centenary Institute have discovered a mechanism that helps control the development of endothelial cells.

Professor Jenny Gamble, Head of the Vascular Biology program at Centenary, says the process by which endothelial progenitor cells (EPCs) change to mature endothelial cells is an important but little understood control.

"If endothelial cell lining is injured or damaged, for example during wound healing, an organ transplant or heart attack, the EPC leave the bone marrow, circulate in the blood and home to the site of the injury where they continue to repair and are induced to become mature cells," she explains.

Publishing in Blood, Professor Gamble and her team found that this process, called differentiation, is partly controlled by the enzyme sphingosine kinase-1.

"We found that high levels of SK-1 keep the cells as EPCs whereas a decrease in the amount of SK-1 allows the cell to differentiate to functionally mature endothelial cells."

By understanding these fundamental tools the body uses to heal itself, there is potential to manipulate this process to create new treatments.

For example, the vascular complications of diabetes are attributed, in part, to the decreased numbers and function of EPCs. Additionally, stents are used extensively for the treatment of cardiovascular disease. However they can often be problematic because of a lack of good endothelial cell coverage.

Centenary Institute Executive Director, Professor Mathew Vadas says an increased understanding of the process of differentiation may allow SK-1 to be manipulated to drive this process and therefore improve treatments of these diseases in the future.

Publication reference

Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Proia RL, Vadas MA, Gamble JR.Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood. 2008 Dec 24. [Epub ahead of print].


Story Source:

The above story is based on materials provided by Centenary Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. S. Bonder, W. Y. Sun, T. Matthews, C. Cassano, X. Li, H. S. Ramshaw, S. M. Pitson, A. F. Lopez, P. T. Coates, R. L. Proia, M. A. Vadas, and J. R. Gamble. Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 2009; 113 (8) [link]

Cite This Page:

Centenary Institute. "Deciphering The Body's Healing Secrets." ScienceDaily. ScienceDaily, 16 February 2009. <www.sciencedaily.com/releases/2009/02/090212093710.htm>.
Centenary Institute. (2009, February 16). Deciphering The Body's Healing Secrets. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2009/02/090212093710.htm
Centenary Institute. "Deciphering The Body's Healing Secrets." ScienceDaily. www.sciencedaily.com/releases/2009/02/090212093710.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins