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Supplement Of Probiotics Provides A New Therapy For Ulcerative Colitis

Date:
February 27, 2009
Source:
World Journal of Gastroenterology
Summary:
Ulcerative colitis (UC) is a non-specific chronic inflammation of intestinal tract and the primary therapies are limited by the side-effects, poor compliance of patient and the high rates of relapse. The supplements of probiotics provide a new therapy for UC. A research group in China compared the effects of four strains of probiotics (E.feacalis, L.acidophilus, C.butyricum and B.adolescentis) in order to find one or two obvious effective strains.

The animal and clinical studies indicated that gastrointestinal bacteria play an important role in the development of UC, and the supplement of probiotics was beneficial for UC. While Because of the specific damage site of UC and the different colonization of each bacterium, it is suggested that different probiotics displayed different effects on UC. The obvious effective strain should be more beneficial for UC.

A research team led by Professor Lu from the Department of Gastroenterology, The Second Xiangya Hospital of Central South University compared the effects of four strains of probiotics which were isolated from healthy human feces by his facility, in order to find one or two obvious effective strains. This investigation showed that all four strains of probiotics (E.feacalis, L.acidophilus, C.butyricum and B.adolescentis) could relieve symptom of experimental colitis close to SASP on an evaluation of weight loss, colon length, DAI scores, histological scores, proteins and mRNA levels of IL-1and Il-4, and MPO. The effectiveness of E.faecalis was better than the other three strains.

Compare with the study that the Germ-free IL-10-/- mice developed IBD after they were colonized with a pure culture of E. faecalis, this study showed that E. faecalis had different effects on experimental colitis in wild-type mice. The experimental results also indicate that there should be some other inflammatory cytokines involved in the difference of adaptive immunological mechanisms in experimental colitis between wide-type mice and the immunodeficient mice except IL-1 and IL-4.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chen LL, Wang XH, Cui Y, Lian GH, Zhang J, Ouyang CH, Lu FG. Therapeutic effects of four strains of probiotics on experimental colitis in mice. World J Gastroenterol, 2009;15(3): 321-327

Cite This Page:

World Journal of Gastroenterology. "Supplement Of Probiotics Provides A New Therapy For Ulcerative Colitis." ScienceDaily. ScienceDaily, 27 February 2009. <www.sciencedaily.com/releases/2009/02/090217125339.htm>.
World Journal of Gastroenterology. (2009, February 27). Supplement Of Probiotics Provides A New Therapy For Ulcerative Colitis. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/02/090217125339.htm
World Journal of Gastroenterology. "Supplement Of Probiotics Provides A New Therapy For Ulcerative Colitis." ScienceDaily. www.sciencedaily.com/releases/2009/02/090217125339.htm (accessed July 23, 2014).

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