Featured Research

from universities, journals, and other organizations

Dividing Cells May Contribute To Alzheimer's Disease

Date:
February 25, 2009
Source:
American Journal of Pathology
Summary:
Dr. Mark Smith and colleagues at Case Western Reserve University found that dysregulated cell cycle control may contribute to neural cell death.

Dr. Mark Smith and colleagues at Case Western Reserve University found that dysregulated cell cycle control may contribute to neural cell death.

Neurodegeneration consists of the progressive loss of structure or function of neurons, often resulting in neural cell death. The causes of cell death in neurodegenerative diseases such as Alzheimer's and Parkinson's are incompletely understood. Mature neurons in healthy individuals do not divide; however, degenerating neurons express a protein, c-Myc (Myc), which regulates cell division.

Lee et al therefore explored the role of re-entry into the cell cycle, leading to cell division, in the neurodegenerative pathogenesis. They found that expression of Myc in forebrain neurons resulted in cell cycle re-entry. Furthermore, Myc expression resulted in neural cell death and cognitive defects. Neurodegeneration, therefore, may be a disease of dysregulated cell-cycle control, and cell-cycle regulators should be explored as future treatment targets.

Dr. Lee and colleagues "strengthen [their] hypothesis that neurodegeneration in [Alzheimer's disease], like cellular proliferation in cancer, is a disease of inappropriate cell cycle control." They "establish a model [that] provides a working platform to test genetic and pharmacologic approaches to block cycle re-entry" and thus explore new methods of treating neurodegenerative diseases.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lee et al. The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse. American Journal Of Pathology, 2009; 174 (3): 891 DOI: 10.2353/ajpath.2009.080583

Cite This Page:

American Journal of Pathology. "Dividing Cells May Contribute To Alzheimer's Disease." ScienceDaily. ScienceDaily, 25 February 2009. <www.sciencedaily.com/releases/2009/02/090223124255.htm>.
American Journal of Pathology. (2009, February 25). Dividing Cells May Contribute To Alzheimer's Disease. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2009/02/090223124255.htm
American Journal of Pathology. "Dividing Cells May Contribute To Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2009/02/090223124255.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins