Featured Research

from universities, journals, and other organizations

Stem Cell Breakthrough: New Method For Creating Stem Cells

Date:
March 2, 2009
Source:
Samuel Lunenfeld Research Institute
Summary:
Scientists have discovered a new method of creating stem cells that could lead to possible cures for devastating diseases including spinal cord injury, macular degeneration, diabetes and Parkinson's disease. The study accelerates stem cell technology and provides a road map for new clinical approaches to regenerative medicine.

Mount Sinai Hospital's Dr. Andras Nagy discovered a new method of creating stem cells that could lead to possible cures for devastating diseases including spinal cord injury, macular degeneration, diabetes and Parkinson's disease. The study, published by Nature, accelerates stem cell technology and provides a road map for new clinical approaches to regenerative medicine.

"We hope that these stem cells will form the basis for treatment for many diseases and conditions that are currently considered incurable," said Dr. Nagy, Senior Investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Investigator at the McEwen Centre for Regenerative Medicine, and Canada Research Chair in Stem Cells and Regeneration. "This new method of generating stem cells does not require embryos as starting points and could be used to generate cells from many adult tissues such as a patient's own skin cells."

Dr. Nagy discovered a new method to create pluripotent stem cells (cells that can develop into most other cell types) without disrupting healthy genes. Dr. Nagy's method uses a novel wrapping procedure to deliver specific genes to reprogram cells into stem cells. Previous approaches required the use of viruses to deliver the required genes, a method that carries the risk of damaging the DNA. Dr. Nagy's method does not require viruses, and so overcomes a major hurdle for the future of safe, personalized stem cell therapies in humans.

"This research is a huge step forward on the path to new stem cell-based therapies and indicates that researchers at the Lunenfeld are at the leading edge of regenerative medicine," said Dr. Jim Woodgett, Director of Research for the Samuel Lunenfeld Research Institute of Mount Sinai Hospital. Regenerative medicine refers to enabling the human body to repair, replace, restore and regenerate its own damaged or diseased cells, tissues and organs.

The research was funded by the Canadian Stem Cell Network and the Juvenile Diabetes Research Foundation (United States).

Dr. Nagy joined Mount Sinai Hospital as a Principal investigator in 1994. In 2005, he created Canada's first embryonic stem cell lines from donated embryos no longer required for reproduction by couples undergoing fertility treatment. That research played a pivotal role in Dr. Nagy's current discovery.

One of the critical components reported in Nagy's paper was developed in the laboratory of Dr. Keisuke Kaji from the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh. Dr. Kaji's findings are also published in the March 1, 2009 issue of Nature. The two papers are highly complementary and further extend Nagy's findings.

"I was very excited when I found stem cell-like cells in my culture dishes. Nobody, including me, thought it was really possible," said Dr. Kaji. "It is a step towards the practical use of reprogrammed cells in medicine."


Story Source:

The above story is based on materials provided by Samuel Lunenfeld Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Woltjen et al. PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature, March 1, 2009; DOI: 10.1038/nature07863

Cite This Page:

Samuel Lunenfeld Research Institute. "Stem Cell Breakthrough: New Method For Creating Stem Cells." ScienceDaily. ScienceDaily, 2 March 2009. <www.sciencedaily.com/releases/2009/03/090301181423.htm>.
Samuel Lunenfeld Research Institute. (2009, March 2). Stem Cell Breakthrough: New Method For Creating Stem Cells. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/03/090301181423.htm
Samuel Lunenfeld Research Institute. "Stem Cell Breakthrough: New Method For Creating Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2009/03/090301181423.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins