Featured Research

from universities, journals, and other organizations

Influenza A Becoming Increasingly Resistant To Drug Oseltamivir

Date:
March 10, 2009
Source:
JAMA and Archives Journals
Summary:
Influenza A viruses (H1N1 subtype) that are resistant to the drug oseltamivir circulated widely in the US during the 2007-2008 influenza season, with an even higher prevalence of drug resistance during the current 2008-2009 influenza season, according to a new study.

Influenza A viruses (H1N1 subtype) that are resistant to the drug oseltamivir circulated widely in the U.S. during the 2007-2008 influenza season, with an even higher prevalence of drug resistance during the current 2008-2009 influenza season, according to a new study.

During the 2007-2008 influenza season, increased levels of resistance to the influenza drug oseltamivir (marketed as Tamiflu) were detected for the first time in the United States and worldwide. In addition, early 2008-2009 influenza season surveillance data suggest that oseltamivir resistance among influenza A(H1N1) viruses will most likely be higher, according to background information in the article. It was unknown whether some resistant viruses would cause clinical illness similar to other influenza viruses.

Nila J. Dharan, M.D., of the Centers for Disease Control and Prevention, Atlanta, and colleagues examined the trends and characteristics of patients infected with oseltamivir-resistant and -susceptible influenza A(H1N1) virus. These viruses, identified and submitted to the CDC by U.S. public health laboratories between September 2007 and May 2008 and between September 28, 2008, and February 19, 2009, were tested as part of ongoing surveillance.

During the 2007-2008 season, influenza A(H1N1) accounted for an estimated 19 percent of circulating influenza viruses in the United States. Resistance to oseltamivir was identified among 142 of 1,155 U.S. influenza A(H1N1) viruses (12 percent) tested during the 2007-2008 influenza season. Data were available for 99 persons infected with oseltamivir-resistant influenza and 182 persons infected with oseltamivir-susceptible influenza from this period.

Among resistant cases, median (midpoint) age was 19 years, 5 patients (5 percent) were hospitalized, and 4 patients (4 percent) died. No significant differences were found between cases of oseltamivir-resistant and oseltamivir-susceptible influenza in demographic characteristics, underlying medical illness, or clinical symptoms. The researchers did not find an association between use of oseltamivir and cases of illness due to infection with oseltamivir-resistant A(H1N1) viruses in the United States.

Preliminary data from the early 2008-2009 influenza season indicates that oseltamivir resistance among A(H1N1) viruses continues at high levels. As of February 19, 2009, resistance to oseltamivir had been identified among 264 of 268 (98.5 percent) U.S. influenza A(H1N1) viruses tested.

"The emergence of oseltamivir resistance has highlighted the need for the development of new antiviral drugs and rapid diagnostic tests that determine viral subtype or resistance, as well as improved representativeness and timeliness of national influenza surveillance for antiviral resistance," the authors write.

They add that on December 19th, 2008, the CDC released interim recommendations for the use of influenza antiviral medications based on the early surveillance data from the 2008-2009 influenza season. "The guidelines recommend that clinicians consider the results of patient testing and local influenza surveillance data on circulating types and subtypes of influenza viruses in deciding whether oseltamivir alone could be used. These guidelines provide options, including preferential use of [the anti-viral drug] zanamivir or a combination of oseltamivir and [the anti-viral drug] rimantadine, which might be more appropriate in treating patients who might have influenza caused by an oseltamivir-resistant virus."

"Additional options for the treatment and prophylaxis of influenza virus infection are critically needed," according to the authors.

Editorial: The Evolution of Influenza Resistance and Treatment

In an accompanying editorial, David M. Weinstock, M.D., of the Dana-Farber Cancer Institute, Boston, and Gianna Zuccotti, M.D., of Brigham and Women's Hospital, Boston, and Contributing Editor, JAMA, Chicago, comment on the findings regarding influenza.

"The understanding of influenza biology and epidemiology has advanced markedly; however, the global dissemination of oseltamivir-resistant influenza came as a great surprise. Undoubtedly, new surprises await in the perpetual struggle with influenza as one thing is certain—the organism will continue to evolve. Anticipating the rapid and endless changes in influenza biology and dynamics will require faster diagnostics to molecularly characterize specimens, extensive surveillance among humans and animals, and more rapid and [flexible] systems for translating basic and epidemiological discoveries into clinically applicable interventions. For now, the best tools to mitigate influenza infection are tried-and-true—vaccination, social distancing, hand washing, and common sense."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nila J. Dharan; Larisa V. Gubareva; John J. Meyer; Margaret Okomo-Adhiambo; Reginald C. McClinton; Steven A. Marshall; Kirsten St. George; Scott Epperson; Lynnette Brammer; Alexander I. Klimov; Joseph S. Bresee; Alicia M. Fry; for the Oseltamivir-Resistance Working Group. Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States. JAMA, 2009;0(2009):2009.294 [link]

Cite This Page:

JAMA and Archives Journals. "Influenza A Becoming Increasingly Resistant To Drug Oseltamivir." ScienceDaily. ScienceDaily, 10 March 2009. <www.sciencedaily.com/releases/2009/03/090302115747.htm>.
JAMA and Archives Journals. (2009, March 10). Influenza A Becoming Increasingly Resistant To Drug Oseltamivir. ScienceDaily. Retrieved September 14, 2014 from www.sciencedaily.com/releases/2009/03/090302115747.htm
JAMA and Archives Journals. "Influenza A Becoming Increasingly Resistant To Drug Oseltamivir." ScienceDaily. www.sciencedaily.com/releases/2009/03/090302115747.htm (accessed September 14, 2014).

Share This



More Health & Medicine News

Sunday, September 14, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins