Featured Research

from universities, journals, and other organizations

Does Supplementation Of Docosahexaenoic Acid Suppress Colon Tumor Cell Growth?

Date:
March 9, 2009
Source:
World Journal of Gastroenterology
Summary:
Prostaglandin E2 is important in the tumorigenesis of colorectal cancer. A new study examined the effects on cancer cell growth of the omega-6 polyunsaturated fatty acid arachidonic acid, a precursor of PGE2, and of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. The results suggest that DHA can inhibit the proliferative effect of abundant AA or PGE2.

Colon cancer is one of the leading causes of death in Western countries. The role of n-3 and n-6 PUFAs in colorectal carcinoma cell growth has not been well studied. It is known that PGE2, generated from AA, is an important factor in the tumorigenesis of colorectal cancer.

Related Articles


However, previous in vitro observations have led to uncertainty regarding a differential role of n-3 and n-6 PUFA for growth of tumor cells, as some findings are contradictory, and most studies have not addressed the effect of a changed n-3/n-6 PUFA ratio on cell proliferation.

A research article to be published on March 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team around Piet Habbel and Karsten H. Weylandt from the Charitι University Hospital in Berlin (Germany) and led by Jing X. Kang from the Massachusetts General Hospital in Boston (USA) used the LS-174T colon cancer cell line, for which several previous studies have shown an important role of PGE2 as growth promoting agent. The study showed differential effects of n-6 PUFA AA and n-3 PUFA DHA. While proliferation was promoted by AA, incubation with DHA reduced cell growth and viability. In addition, this study demonstrated that the n-3 PUFA DHA can directly suppress AA- as well as PGE2-induced colon cancer cell growth.

These results add evidence to the argument that the ratio of n-6/n-3 PUFA (and in particular the ratio of AA versus DHA) may be a critical determinant of proliferation and tumor growth in the colon, and that DHA supplementation can suppress tumor cell growth, even in the presence of high AA- and PGE2 levels. These results suggest that supplementation of DHA may be a powerful tool to counteract AA- and PGE2-promoted colon cancer cell growth that is associated with the predominant Western diet.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Habbel et al. Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. World Journal of Gastroenterology, 2009; 15 (9): 1079 DOI: 10.3748/wjg.15.1079

Cite This Page:

World Journal of Gastroenterology. "Does Supplementation Of Docosahexaenoic Acid Suppress Colon Tumor Cell Growth?." ScienceDaily. ScienceDaily, 9 March 2009. <www.sciencedaily.com/releases/2009/03/090309093044.htm>.
World Journal of Gastroenterology. (2009, March 9). Does Supplementation Of Docosahexaenoic Acid Suppress Colon Tumor Cell Growth?. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2009/03/090309093044.htm
World Journal of Gastroenterology. "Does Supplementation Of Docosahexaenoic Acid Suppress Colon Tumor Cell Growth?." ScienceDaily. www.sciencedaily.com/releases/2009/03/090309093044.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins