Featured Research

from universities, journals, and other organizations

New Human Genetic Link To High Levels Of 'Good' Cholesterol

Date:
March 20, 2009
Source:
Journal of Clinical Investigation
Summary:
HDL cholesterol, or "good" cholesterol, helps eliminate excess "bad" cholesterol that might otherwise block arteries. As such, individuals with high plasma HDL cholesterol levels have a decreased risk of coronary artery disease. Researchers now show that mutations in the LIPG gene, which codes for the enzyme endothelial lipase, result in high plasma HDL cholesterol levels, providing important human genetic evidence that inhibition of endothelial lipase is likely to raise "good" cholesterol levels.

HDL cholesterol, or "good" cholesterol, helps eliminate excess "bad" cholesterol that might otherwise block arteries. As such, individuals with high plasma HDL cholesterol levels have a decreased risk of coronary artery disease.

University of Pennsylvania researchers now show that mutations in the LIPG gene, which codes for the enzyme endothelial lipase, result in high plasma HDL cholesterol levels, providing important human genetic evidence that inhibition of endothelial lipase is likely to raise "good" cholesterol levels.

HDL cholesterol (HDL-C), or "good" cholesterol, carries excess cholesterol – that might otherwise block arteries – from blood vessels back to the liver for processing and elimination. As such, individuals with high plasma HDL-C levels have a decreased risk of developing coronary artery disease.

Genetics contribute to determining a person's plasma HDL-C level, and in a new JCI study Daniel Rader and colleagues from the University of Pennsylvania show that mutations in the LIPG gene, which codes for an enzyme known as endothelial lipase, result in high plasma HDL-C levels.

The authors examined the LIPG gene in 585 subjects of European ancestry and identified 10 people with previously unreported rare mutated forms of this gene that were unique to subjects with very high HDL-C levels. Further studies revealed that mutations in the LIPG gene that cause loss of endothelial lipase activity were the cause of increased plasma HDL-C levels.

These data provide important human genetic evidence that inhibition of endothelial lipase is likely to raise HDL-C levels in humans. Whether or not the resulting increase in HDL-C level due to this inhibition would impact cardiovascular health requires further study.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Edmondson et al. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI37176

Cite This Page:

Journal of Clinical Investigation. "New Human Genetic Link To High Levels Of 'Good' Cholesterol." ScienceDaily. ScienceDaily, 20 March 2009. <www.sciencedaily.com/releases/2009/03/090316173311.htm>.
Journal of Clinical Investigation. (2009, March 20). New Human Genetic Link To High Levels Of 'Good' Cholesterol. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/03/090316173311.htm
Journal of Clinical Investigation. "New Human Genetic Link To High Levels Of 'Good' Cholesterol." ScienceDaily. www.sciencedaily.com/releases/2009/03/090316173311.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) — A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) — The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) — After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) — Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins