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High Prevalence Of Infection With Three Recently Discovered Human Polyomaviruses

Date:
April 3, 2009
Source:
Public Library of Science
Summary:
A majority of the human population has been exposed to newly discovered KI (KIV), WU (WUV), and Merkel cell (MCV) human polyomaviruses, according to a new study. The results, based on antibody measurements in serum samples, also suggest that infection with these viruses occurs early in childhood.

A majority of the human population has been exposed to newly discovered KI (KIV), WU (WUV), and Merkel cell (MCV) human polyomaviruses, according to a new study by researchers at the University of Colorado. The results, based on antibody measurements in serum samples, also suggest that infection with these viruses occurs early in childhood.

For over 30 years, scientists have known about two human polyomaviruses, BKV and JCV. Within the past two years, however, three new viruses have been described that belong to this same virus family. KIV and WUV were detected in nasal secretions, and may be respiratory viruses. MCV was discovered in Merkel Cell carcinomas, a rare skin cancer. Further studies are needed to determine what fraction of the human population has been infected with these viruses and when initial exposure occurs.

In this study, Kean and colleagues tested over 2220 anonymous donor blood samples (more than1500 adult and more than 700 pediatric [< 21 years of age]) They measured antibodies that reacted with specific viral proteins. In addition to KIV, WUV, MCV, BKV, and JCV, two monkey polyomaviruses, SV40 and lymphotropic polyomavirus (LPV), were also studied. Antibodies to LPV were detected in a fraction of people (15%), confirming previous studies suggesting that a relative of this virus may infect humans. The majority of antibodies against SV40 proteins may be attributed to the immune response to BKV. The diseases caused by these viruses remain to be fully described.

The samples and results reported are likely representative of infection in the Denver metropolitan area where they were collected. Future studies will be important to help determine differences in the prevalence of these infections in other geographic areas.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kean JM, Rao S, Wang M, Garcea RL. Seroepidemiology of Human Polyomaviruses. PLoS Pathog, e1000363 DOI: 10.1371/journal.ppat.1000363

Cite This Page:

Public Library of Science. "High Prevalence Of Infection With Three Recently Discovered Human Polyomaviruses." ScienceDaily. ScienceDaily, 3 April 2009. <www.sciencedaily.com/releases/2009/03/090326215052.htm>.
Public Library of Science. (2009, April 3). High Prevalence Of Infection With Three Recently Discovered Human Polyomaviruses. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/03/090326215052.htm
Public Library of Science. "High Prevalence Of Infection With Three Recently Discovered Human Polyomaviruses." ScienceDaily. www.sciencedaily.com/releases/2009/03/090326215052.htm (accessed April 23, 2014).

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