Featured Research

from universities, journals, and other organizations

Girls Lacking The Protein ITK At Risk From Fatal Viral Infection

Date:
April 12, 2009
Source:
Journal of Clinical Investigation
Summary:
One of the most common viruses to infect humans is EBV. Although most people show no or few signs of infection, some develop glandular fever and boys with mutations in either one of two genes on the X-chromosome (SAP and XIAP) develop a fatal lymphoproliferative disease.

One of the most common viruses to infect humans is EBV. Although most people show no or few signs of infection, some develop glandular fever and boys with mutations in either one of two genes on the X-chromosome (SAP and XIAP) develop a fatal lymphoproliferative disease.

Arndt Borkhardt and colleagues, at Heinrich Heine University, Germany, have now identified two girls from a consanguineous Turkish family who died after becoming infected with EBV and developing a lymphoproliferative disorder clinically resembling that observed in EBV-infected boys deficient for SAP or XIAP.

Detailed analysis revealed that the girls had a mutation in both copies of their ITK gene that rendered them deficient in ITK protein.

The authors therefore suggest that ITK deficiency should be considered as a cause of EBV-associated lymphoproliferative disorders by those diagnosing and treating patients.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Huck et al. Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI37901

Cite This Page:

Journal of Clinical Investigation. "Girls Lacking The Protein ITK At Risk From Fatal Viral Infection." ScienceDaily. ScienceDaily, 12 April 2009. <www.sciencedaily.com/releases/2009/04/090401181221.htm>.
Journal of Clinical Investigation. (2009, April 12). Girls Lacking The Protein ITK At Risk From Fatal Viral Infection. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/04/090401181221.htm
Journal of Clinical Investigation. "Girls Lacking The Protein ITK At Risk From Fatal Viral Infection." ScienceDaily. www.sciencedaily.com/releases/2009/04/090401181221.htm (accessed July 24, 2014).

Share This




More Plants & Animals News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins