Featured Research

from universities, journals, and other organizations

Girls Lacking The Protein ITK At Risk From Fatal Viral Infection

Date:
April 12, 2009
Source:
Journal of Clinical Investigation
Summary:
One of the most common viruses to infect humans is EBV. Although most people show no or few signs of infection, some develop glandular fever and boys with mutations in either one of two genes on the X-chromosome (SAP and XIAP) develop a fatal lymphoproliferative disease.

One of the most common viruses to infect humans is EBV. Although most people show no or few signs of infection, some develop glandular fever and boys with mutations in either one of two genes on the X-chromosome (SAP and XIAP) develop a fatal lymphoproliferative disease.

Arndt Borkhardt and colleagues, at Heinrich Heine University, Germany, have now identified two girls from a consanguineous Turkish family who died after becoming infected with EBV and developing a lymphoproliferative disorder clinically resembling that observed in EBV-infected boys deficient for SAP or XIAP.

Detailed analysis revealed that the girls had a mutation in both copies of their ITK gene that rendered them deficient in ITK protein.

The authors therefore suggest that ITK deficiency should be considered as a cause of EBV-associated lymphoproliferative disorders by those diagnosing and treating patients.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Huck et al. Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI37901

Cite This Page:

Journal of Clinical Investigation. "Girls Lacking The Protein ITK At Risk From Fatal Viral Infection." ScienceDaily. ScienceDaily, 12 April 2009. <www.sciencedaily.com/releases/2009/04/090401181221.htm>.
Journal of Clinical Investigation. (2009, April 12). Girls Lacking The Protein ITK At Risk From Fatal Viral Infection. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2009/04/090401181221.htm
Journal of Clinical Investigation. "Girls Lacking The Protein ITK At Risk From Fatal Viral Infection." ScienceDaily. www.sciencedaily.com/releases/2009/04/090401181221.htm (accessed August 21, 2014).

Share This




More Plants & Animals News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) — According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) — According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Ramen Health Risks: The Dark Side of the Noodle

Ramen Health Risks: The Dark Side of the Noodle

AP (Aug. 21, 2014) — South Koreans eat more instant ramen noodles per capita than anywhere else in the world. But American researchers say eating too much may increase the risk of diabetes, heart disease and stroke. (Aug. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins