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Human Brains Make Their Own 'Marijuana'

Date:
April 20, 2009
Source:
Federation of American Societies for Experimental Biology
Summary:
Scientists have discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery may lead to new marijuana-like drugs for managing pain, stimulating appetite and preventing marijuana abuse.

Marijuana plant. Scientists have just shown that one of Bob Dylan's most famous lines--"everybody must get stoned"-- is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself.
Credit: iStockphoto

U.S. and Brazilian scientists have discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery may lead to new marijuana-like drugs for managing pain, stimulating appetite, and preventing marijuana abuse.

"Ideally, this development will lead to drugs that bind to and activate the THC receptor, but are devoid of the side effects that limit the usefulness of marijuana," said Lakshmi A. Devi of the Department of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine in New York and one of the senior researchers involved in the study. "It would be helpful to have a drug that activated or blocked the THC receptor, and our findings raise the possibility that this will lead to effective drugs with fewer side effects."

Scientists made their discovery by first extracting several small proteins, called peptides, from the brains of mice and determining their amino acid sequence. The extracted proteins were then compared with another peptide previously known to bind to, but not activate, the receptor (THC) affected by marijuana. Out of the extracted proteins, several not only bound to the brain's THC receptors, but activated them as well.

"The War on Drugs has hit very close to home," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Last year, scientists found that our skin makes its own marijuana-like substance. Now, we see that our brain has been making proteins that act directly on the marijuana receptors in our head. The next step is for scientists to come up with new medicines that eliminate the nasty side of pot—a better joint, so to speak."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ivone Gomes, Julia S. Grushko, Urszula Golebiewska, Sascha Hoogendoorn, Achla Gupta, Andrea S. Heimann, Emer S. Ferro, Suzanne Scarlata, Lloyd D. Fricker, and Lakshmi A. Devi. Novel endogenous peptide agonists of cannabinoid receptors. FASEB J, DOI: 10.1096/fj.09-132142

Cite This Page:

Federation of American Societies for Experimental Biology. "Human Brains Make Their Own 'Marijuana'." ScienceDaily. ScienceDaily, 20 April 2009. <www.sciencedaily.com/releases/2009/04/090420151240.htm>.
Federation of American Societies for Experimental Biology. (2009, April 20). Human Brains Make Their Own 'Marijuana'. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2009/04/090420151240.htm
Federation of American Societies for Experimental Biology. "Human Brains Make Their Own 'Marijuana'." ScienceDaily. www.sciencedaily.com/releases/2009/04/090420151240.htm (accessed September 1, 2014).

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