Featured Research

from universities, journals, and other organizations

3-D Research Model Tackles Prostate Cancer Spread

Date:
April 24, 2009
Source:
Queensland University of Technology
Summary:
One of the few research projects to study the spread of prostate cancer to the bones using 3-D models of tissue-engineered bone is now underway.

One of the few research projects to study the spread of prostate cancer to the bones using three-dimensional models of tissue-engineered bone is underway at QUT's Institute of Health and Biomedical Innovation (IHBI).

Shirly Sieh, a PhD student at IHBI, is studying the way cancer cells escape from the prostate through the bloodstream to form tumour colonies, most often in the spine and long bones.

"It is an innovative study which uses a tissue engineering platform technology developed by IHBI's Professor Dietmar W. Hutmacher in order to investigate the interaction between bones and cancer cells," Ms Sieh said.

"Tissue-engineered bone provides the 3D architecture for the cancer cells which more closely resemble bone metastasis instead of growing the cancer cells and bone cells on a flat Petrie dish.

"I am growing prostate cancer cells on the tissue-engineered bone to observe the interactions between the cells and the surrounding tissue so it is a way of mimicking the cancer cells invading the bone environment."

Ms Sieh said it was still not clear to researchers how bones and cancer cells interacted.

"With this 3D method we can see if and how the cancer cells 'set up home' in the bone cells," she said.

"We want to study how the cancer cells degrade the matrix, or the mix of proteins and growth factors produced by these cells, and remodel the environment to suit the cancer cells to grow a tumour."

Ms Sieh said scientists also wanted to understand why prostate cancer cells were attracted to the bone sites. She and Amy Lubik, a PhD student supervised by Professor Colleen Nelson, are studying the effect the cancer cells in the bone have on male hormone production, particularly on the hormone, androgen.

"People with advanced cancer who have had prostate removal surgery should have low levels of androgen and the cancer cells should be suppressed. However, sometimes the cancer cells do recur," she said.

"We think it might have something to do with the fact that the cancer cells are very sensitive to androgen and even low levels of androgen in the body could promote the growth of these cancer cells."

Ms Sieh said previous research had found that when the prostate cancer cells changed the bone environment they eventually induced more bone formation.

"But it is very abnormal growth which can cause bone fractures and painful spinal compression for the person," she said.


Story Source:

The above story is based on materials provided by Queensland University of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Queensland University of Technology. "3-D Research Model Tackles Prostate Cancer Spread." ScienceDaily. ScienceDaily, 24 April 2009. <www.sciencedaily.com/releases/2009/04/090424114210.htm>.
Queensland University of Technology. (2009, April 24). 3-D Research Model Tackles Prostate Cancer Spread. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/04/090424114210.htm
Queensland University of Technology. "3-D Research Model Tackles Prostate Cancer Spread." ScienceDaily. www.sciencedaily.com/releases/2009/04/090424114210.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins