Featured Research

from universities, journals, and other organizations

Newly Discovered Mechanism Promotes Blood Clot Formation

Date:
May 26, 2009
Source:
Monash University
Summary:
Researchers in Australia have discovered an entirely new mechanism that promotes blood clot formation -- a major breakthrough that will impact on treatment and prevention of heart disease and stroke.

A Monash-led research team has discovered an entirely new mechanism that promotes blood clot formation – a major breakthrough that will impact on treatment and prevention of heart disease and stroke.

The discovery is published in the journal Nature Medicine.

The discovery is the result of a decade-long research project led by Professor Shaun Jackson, Dr Warwick Nesbitt and Erik Westein from the Australian Centre for Blood Diseases (ACBD) at Monash University.

The study has discovered a new link between disturbed blood flow and blood clotting. ACBD research director Professor Shaun Jackson said that the association between disturbed blood flow and blood clotting was identified more than 150 years ago however it has proven extremely difficult to work out the mechanism by which blood flow activates the clotting mechanism.

"Changes in our arteries are a normal feature of the ageing process leading to disturbances in blood flow. Our work identifies the precise mechanism by which these blood flow changes activate the clotting process, increasing the risk of heart attack and stroke," Professor Jackson said.

Working in collaboration with scientists in the Department of Mechanical Engineering and the Division of Biological Engineering, Monash University and the School of Electronics and Computer Engineering at RMIT University in Melbourne, the ACBD researchers developed sophisticated new techniques that have helped define the link between disturbed blood flow and clot formation.

Lead author Dr Nesbitt explains that this new clotting mechanism is not sensitive to anti-clotting drugs, such as aspirin, clopidogrel or warfarin, defining an important new mechanism responsible for anti-clotting drug resistance.

"This discovery may partly explain the lack of effectiveness of commonly used anti-clotting therapies and may also lead to the development of new and innovative approaches to prevent heart disease and stroke." Dr Nesbitt said.

Blood clotting diseases are Australia's major healthcare problem affecting more than 50 per cent the adult population and kills one Australian nearly every ten minutes. The development of a clot in the circulation to the heart or brain (causing a heart attack or stroke, respectively) is an enormous clinical problem, responsible for more deaths in the community than any other disease.

Despite intense investigation over the last 40 years into the discovery and development of more effective anti-clotting drugs, the impact of these therapies on mortality rates has remained disappointingly low, with less than one in six patients taking anti-clotting therapies avoiding a fatal clotting event.

Mr Westein, co-lead author of the study, said the situation was likely to worsen in the future due to the rapidly growing incidence of obesity and diabetes. "People with diabetes are typically more resistant to the benefits of anti-clotting therapy, thus there is a pressing need for the identification and development of more effective approaches in the prevention of blood clotting," Mr Westein said.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Warwick S Nesbitt, Erik Westein, Francisco Javier Tovar-Lopez, Elham Tolouei, Arnan Mitchell, Jia Fu, Josie Carberry, Andreas Fouras & Shaun P Jackson. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nature Medicine, 2009; DOI: 10.1038/nm.1955

Cite This Page:

Monash University. "Newly Discovered Mechanism Promotes Blood Clot Formation." ScienceDaily. ScienceDaily, 26 May 2009. <www.sciencedaily.com/releases/2009/05/090526094300.htm>.
Monash University. (2009, May 26). Newly Discovered Mechanism Promotes Blood Clot Formation. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/05/090526094300.htm
Monash University. "Newly Discovered Mechanism Promotes Blood Clot Formation." ScienceDaily. www.sciencedaily.com/releases/2009/05/090526094300.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins