Featured Research

from universities, journals, and other organizations

Some Donor Factors Affect Outcomes For HCV-positive Liver Transplant Recipients

Date:
May 28, 2009
Source:
Wiley-Blackwell
Summary:
Two new studies address donor factors that could affect outcomes for liver transplant recipients, particularly those with chronic hepatitis C (HCV). One found that donor steatosis, or fat in the liver, does not affect liver disease progression or three-year survival in recipients with or without HCV.

Two new studies address donor factors that could affect outcomes for liver transplant recipients, particularly those with chronic hepatitis C (HCV). One found that donor steatosis, or fat in the liver, does not affect liver disease progression or three-year survival in recipients with or without HCV. However, transplants from people higher on the Donor Risk Index did adversely affect the outcomes of HCV-positive recipients more than recipients without HCV.

These studies are in the June issue of Liver Transplantation, a journal published by John Wiley & Sons.

HCV is a common cause of end-stage liver disease. It accounts for almost half of the patients awaiting a liver transplant, 15 percent of whom will die before an organ becomes available. To address this critical shortage, researchers have searched for ways to expand the pool of potential donors. They have tried living donor liver transplantation, partial liver transplants, and the use of grafts from donors who may be less than ideal. Sub-optimal donors might include those of advanced age or with other medical conditions such as hepatic steatosis, also known as fatty liver disease, which is common in overweight individuals.

Researchers led by Patrizia Burra of Padova, Italy examined the impact of donor livers with steatosis on recipients with and without HCV. They included 116 consecutive liver transplants on 56 HCV-positive and 60 HCV-negative recipients and followed-up with liver biopsies at 6, 12, 24 and 36 months.

“There was no correlation between donor graft steatosis and fibrosis after liver transplantation, irrespective of the etiology of liver disease,” the authors report. They also found no evidence that steatosis affected patient survival up to three years post-transplant.

In another study, researchers led by Daniel Maluf of Virginia Commonwealth University performed a retrospective analysis of 16,678 patients who received a liver transplant between January 2000 and June 2006. They examined the impact of the donor risk index (DRI) on patient outcomes.

“Increasing DRI was associated with a statistically significant increase in the relative risk of graft failure and patient death for both HCV-positive and HCV-negative individuals,” they report. “However, HCV-positive recipients demonstrated a significantly higher increase in relative risk of patient and graft loss as a function of the DRI than HCV-negative subjects, even after adjustment for several recipient factors including MELD.”

Donor age was the most significant, but not the only, factor that correlated to worse outcomes. The authors concluded that high DRI grafts should be used carefully in HCV-positive patients.

In an accompanying editorial, Sandy Feng of the UCSF Medical Center, supports the findings of these new studies, and highlights the need to focus on survival benefit for liver transplant recipients in a time of donor organ shortage.

“It is now possible to create an allocation algorithm that can systematically and objectively account for the variable impact of donor characteristics on liver transplant outcomes within the context of recipient diagnosis and disease severity,” she concludes. “I believe that this would be the most equitable and transparent way to distribute the differential risk posed by the donor pool to individual transplant candidates.”


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. Maluf, Daniel; Edwards, Erick; Stravitz, R.; Kauffman, H. Impact of the Donor Risk Index in the Outcome of HCV Liver Transplant Recipients. Liver Transplantation, June 2009
  2. Burra, Patrizia; Loreno, Massimiliano; Russo, Francesco; Germani, Giacomo; Galligioni, Alessandra; Senzolo, Marco; Cillo, Umberto; Zanus, Giacomo; Fagiuoli, Stefano; Rugge, Massimo. Donor Livers with Steatosis are Safe to Use in HCV-Positive Recipients. Liver Transplantation, June 2009
  3. Feng, Sandy. Increased Donor Risk%u2014Who Should Bear the Burden. Liver Transplantation, June 2009

Cite This Page:

Wiley-Blackwell. "Some Donor Factors Affect Outcomes For HCV-positive Liver Transplant Recipients." ScienceDaily. ScienceDaily, 28 May 2009. <www.sciencedaily.com/releases/2009/05/090528142848.htm>.
Wiley-Blackwell. (2009, May 28). Some Donor Factors Affect Outcomes For HCV-positive Liver Transplant Recipients. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/05/090528142848.htm
Wiley-Blackwell. "Some Donor Factors Affect Outcomes For HCV-positive Liver Transplant Recipients." ScienceDaily. www.sciencedaily.com/releases/2009/05/090528142848.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins