Featured Research

from universities, journals, and other organizations

Unexpected Discovery Can Open A New Chapter In The Fight Against Tuberculosis

Date:
June 9, 2009
Source:
Uppsala University
Summary:
A close relative of the microorganism that causes tuberculosis in humans has been found to form spores. This discovery might constitute a new turn in the fight against human tuberculosis.

A close relative of the microorganism that causes tuberculosis in humans has been found to form spores. This is a sensational finding because researchers have long been convinced that these kinds of bacteria–the mycobacteria–were incapable of forming spores. Leif Kirsebom's research group at Uppsala University now has photographic proof, obtained while working with the bacteria that causes tuberculosis in fish, to challenge this long-held belief. Their discovery, which has attracted much attention from other scientists, might constitute a new turn in the fight against human tuberculosis.

"This opens a completely new chapter in mycobacteriology. Now we can perhaps understand how mycobacteria 'hibernate' and cause latent infections," says Leif Kirsebom.

To "hibernate", many types of bacteria generate spores. Anthrax bacteria are a well-known example of this. Spores are stabile and can remain inactive for many years. Bacteria will often form spores when faced with harsh conditions, such as a drastic decrease in nutrition. However, the discovery that mycobacteria can produce spores means that even this group of microorganisms has the ability to "hibernate". The Uppsala research group's pioneering discovery was completely unexpected. In fact, it was the result of a sidetrack in a study on something entirely different, RNA.

"In our studies we noticed something strange that we wondered about, but it wasn't until I received funding to take up a completely new line of research that we took the opportunity to examine more closely the strange finding that we were seeing," says Leif Kirsebom.

The microorganism that causes human tuberculosis, Mycobacterium tuberculosis, was identified in 1882 by the German microbiologist, Robert Koch. Every year ten million new cases of tuberculosis are diagnosed and two to three million people die of the disease. Treatment is difficult because the microorganism is becoming increasingly resistant to antibiotics. It is estimated that a third of the world's population carries the microorganism latently, without any symptoms of the disease.

"This means that the disease can break out much later, even decades after the initial infection," explains Leif Kirsebom.

Little is known about tuberculosis bacteria during this latent stage of the disease. It has been suggested that they are somehow "sleeping" or that their growth is retarded by the infected host's immune system. This lack of knowledge about how they "hibernate" applies to the other kinds mycobacteria as well. Mycobacteria are found everywhere in our environment–in groundwater and tap water, in humans and animals. Besides tuberculosis, they cause many other serious diseases, for example Buruli ulcer and leprosy in humans and Johne's disease in cattle. Even the intestinal disease, Crohn's, is believed to be linked to mycobacteria. The discovery that mycobacteria can form spores opens entirely new avenues to understanding how they "hibernate" and spread.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Cite This Page:

Uppsala University. "Unexpected Discovery Can Open A New Chapter In The Fight Against Tuberculosis." ScienceDaily. ScienceDaily, 9 June 2009. <www.sciencedaily.com/releases/2009/06/090608182437.htm>.
Uppsala University. (2009, June 9). Unexpected Discovery Can Open A New Chapter In The Fight Against Tuberculosis. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/06/090608182437.htm
Uppsala University. "Unexpected Discovery Can Open A New Chapter In The Fight Against Tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2009/06/090608182437.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins