Featured Research

from universities, journals, and other organizations

Myeloid Proteins Reflect Disease Activity And Treatment Response In Familial Mediterranean Fever

Date:
June 11, 2009
Source:
European League Against Rheumatism
Summary:
Serum levels of the pro-inflammatory biomarkers myeloid-related protein 8 and 14 are increased to a greater extent in patients with Familial Mediterranean Fever during flare than in patients with neonatal-onset multisystem inflammatory disease or patients with Muckle Wells syndrome, according to new research.

Serum levels of the pro-inflammatory biomarkers myeloid-related protein (MRP) 8 and 14 are increased to a greater extent in patients with Familial Mediterranean Fever (FMF) during flare than in patients with Neonatal-Onset Multisystem Inflammatory Disease (NOMID) or patients with Muckle Wells Syndrome (MWS), according to the results of a new study presented June 11 at PReS 2009, a joint congress with the 2009 Congress of the European League Against Rheumatism (EULAR) in Copenhagen, Denmark.

Related Articles


Results of the study indicate that measurement of levels of these biomarkers may enable the prediction of: disease activity, response to anti-inflammatory treatment, differentiation of disorders leading to Fever of Unknown Origin and, potentially, detection of subclinical inflammatory activity in children and adolescents with FMF.

Dr Helmut Wittkowski of the University Hospital Muenster, Germany, who led the study said: "The identification of the role of MRP8/14 during high inflammatory episodes, as well as during successful therapy, offers new insight into the complex underlying mechanisms involved in FMF. Tracking levels of MRP 8/14 may prove a marker for disease activity in FMF and may even lead to earlier diagnosis and improved treatment options for this unique patient population."

MRP8/14 are endogenous danger-signals (damage-associated molecular pattern (DAMP) molecules) that play an important role in inflammatory and immunological responses. They have recently been identified as activators of toll like receptor 4 (TLR-4), a molecule that amplifies phagocyte activation (a type of white blood cell, leucocyte), supporting the immune system by neutralising or engulfing bacteria or other invading micro-organisms.

The mean serum levels of MRP8/14 in inflammatory episodes of FMF (343.210202.210 ng/ml) were found to be significantly higher than in NOMID (2.830580 ng/ml; p< 0,001) or in MWS (3.205585 ng/ml; p< 0,001). FMF patients treated with colchicine (a commonly-used long-term treatment for the condition) and not exhibiting any flares during the study period (54801900 ng/ml) had significantly lower MRP8/14 levels than patients treated with colchicine exhibiting complaints typical for FMF (34.70014.580 ng/ml; p< 0,001), and also than homozygous (having copies of the FMF gene from both parents) patients without symptoms or treatment (22.31010.110 ng/ml; p< 0,05).

FMF is a hereditary inflammatory disorder that affects groups of people with a genetic lineage originating from around the Mediterranean Sea. First symptoms usually occur before the age of 18 years and are rare in those over the age of 40 years. FMF is characterised by recurrent, painful, inflammatory attacks lasting between 6 and 72 hours, most of which involve fever and can affect serous tissues in different parts of the body including the abdomen, joints and chest.

In the study, serum concentrations of MRP8/14 were analysed in 51 children and adolescents who had a clinical and/or genetic diagnosis of FMF, using a bespoke ELISA (Enzyme Linked Immunosorbent Assay) system. 17 Neonatal-Onset Multisystem Inflammatory Disease (NOMID) patients and 18 Muckle Wells Syndrome (MWS) patients were used as study controls.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Myeloid Proteins Reflect Disease Activity And Treatment Response In Familial Mediterranean Fever." ScienceDaily. ScienceDaily, 11 June 2009. <www.sciencedaily.com/releases/2009/06/090611110826.htm>.
European League Against Rheumatism. (2009, June 11). Myeloid Proteins Reflect Disease Activity And Treatment Response In Familial Mediterranean Fever. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2009/06/090611110826.htm
European League Against Rheumatism. "Myeloid Proteins Reflect Disease Activity And Treatment Response In Familial Mediterranean Fever." ScienceDaily. www.sciencedaily.com/releases/2009/06/090611110826.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins