Featured Research

from universities, journals, and other organizations

Psoriasis Associated With Cardiovascular Disease And Increased Mortality

Date:
June 17, 2009
Source:
JAMA and Archives Journals
Summary:
The skin disease psoriasis is associated with atherosclerosis (a buildup of plaque in the arteries) characterized by an increased prevalence of ischemic heart disease, cerebrovascular disease, peripheral artery disease and an increased risk of death, according to a new article.

The skin disease psoriasis is associated with atherosclerosis (a buildup of plaque in the arteries) characterized by an increased prevalence of ischemic heart disease, cerebrovascular disease, peripheral artery disease and an increased risk of death, according to a new article.

Psoriasis affects nearly 2 percent to 3 percent of the world's population, including 7 million Americans, according to background information in the article. In addition to its effects on the skin, psoriasis is associated with arthritis, depression and a lower quality of life. "More recently, psoriasis has also been shown to be a systemic inflammatory condition, with similarities to other inflammatory immune disorders," the authors write. "Since the riswww.jamamedia.orgk of myocardial infarction is increased in rheumatoid arthritis and systemic lupus erythematosus, which are both inflammatory conditions, attention has been focused on the association between psoriasis, cardiovascular risk factors and myocardial infarction."

Srjdan Prodanovich, M.D., of the University of Miami Miller School of Medicine, and colleagues analyzed the computerized records of 3,236 patients with psoriasis and 2,500 individuals without psoriasis who were seen at the same Veterans Administration facility. Patients in the psoriasis group were slightly older than those in the control group without psoriasis (average age 67.9 vs. 65.1) and were more likely to be men (95.5 percent vs. 88.2 percent).

"After age, sex and history of hypertension, diabetes, dyslipidemia [abnormal cholesterol levels] and smoking status were controlled for, patients with psoriasis were significantly more likely than controls to carry a diagnosis of atherosclerosis," the authors write. Patients with psoriasis were also more likely to have an additional diagnosis of another blood vessel disease, including ischemic heart disease (affecting vessels leading to the heart), cerebral vascular disease (vessels leading to the brain) or peripheral arterial disease (vessels outside the heart and brain).

"This result is not surprising, given the systemic nature of atherosclerosis," the authors write. "It has tremendous and far-reaching clinical implications, as all of these vascular conditions represent a major financial cost to the health care system as well as a major cause of disability and death. The latter finding was corroborated by our analysis, whereby we concluded that psoriasis is an independent risk factor for mortality; i.e., we found a higher percentage of deaths among patients with psoriasis than among patients without psoriasis (19.6 percent vs. 9.9 percent)."

Future studies should investigate whether aggressive treatment of either cardiovascular risk factors or psoriasis will lead to an improvement in atherosclerosis in these patients, the authors conclude. "In the meantime, we recommend that health care providers who are caring for patients with psoriasis be vigilant with respect to traditional risk factor screenings," they write. "It would be prudent for dermatologists to be familiar with suggested screening for cardiovascular risk factors and recommendations for aspirin use. If not, it is imperative that they work in collaboration with a primary care provider or another internal medicine specialist, who also needs to be aware of our findings."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Srjdan Prodanovich; Robert S. Kirsner; Jeffrey D. Kravetz; Fangchao Ma; Lisa Martinez; Daniel G. Federman. Association of Psoriasis With Coronary Artery, Cerebrovascular, and Peripheral Vascular Diseases and Mortality. Arch Dermatol., 2009; 145(6):700-703. [link]

Cite This Page:

JAMA and Archives Journals. "Psoriasis Associated With Cardiovascular Disease And Increased Mortality." ScienceDaily. ScienceDaily, 17 June 2009. <www.sciencedaily.com/releases/2009/06/090615161701.htm>.
JAMA and Archives Journals. (2009, June 17). Psoriasis Associated With Cardiovascular Disease And Increased Mortality. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/06/090615161701.htm
JAMA and Archives Journals. "Psoriasis Associated With Cardiovascular Disease And Increased Mortality." ScienceDaily. www.sciencedaily.com/releases/2009/06/090615161701.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins