Featured Research

from universities, journals, and other organizations

Protein That Protects Sperm, Reduces Miscarriage Rates Identified

Date:
June 26, 2009
Source:
Journal of Clinical Investigation
Summary:
Researchers have identified a protein that helps protect immature mouse sperm from oxidative stress. When male mice over one year old lacking this protein were mated with normal female mice, an increased incidence of miscarriages and fetal developmental defects were observed. These data have clinical relevance, as age-related DNA damage to human sperm is associated with decreased fertility and increased rates of miscarriage and childhood disease.

Researchers have identified a protein that helps protect immature mouse sperm from oxidative stress. When male mice over one year old lacking this protein were mated with normal female mice, an increased incidence of miscarriages and fetal developmental defects were observed.

Related Articles


These data have clinical relevance, as age-related DNA damage to human sperm is associated with decreased fertility and increased rates of miscarriage and childhood disease.

Joel Drevet and colleagues, at Clermont Universitι, France, have identified a protein that helps protect immature mouse sperm after they have been released into a region of the testis known as the epididymis, which is where they undergo maturation.

Although male mice lacking this protein, Gpx5, had normal looking sperm and were equally as efficient as normal male mice at fertilizing female mice, an increased incidence of miscarriages and fetal developmental defects were observed when normal female mice were mated with Gpx5-deficient males over 1 year old compared with normal male mice of the same age.

Further analysis indicated that Gpx5 acts as an antioxidant in the epididymis, protecting the sperm from oxidative stress. As discussed by the authors, and, in an accompanying commentary, John Aitken, at the University of Newcastle, Australia, these data have immense clinical relevance as age-related DNA damage to human sperm has been associated with a range of adverse outcomes including decreased fertility, and increased rates of miscarriage and childhood disease.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. J. Aitken. Gpx5 protects the family jewels. Journal of Clinical Investigation, July 2009
  2. E. Chabory, C. Damon, A. Lenoir, G. Kauselmann, H. Kern, B. Zevnik, C. Garrel, F. Saez, R. Cadet, J. Henry-Berger, M. Schoor, U. Gottwald, U. Habenicht, J. R. Drevet and P. Vernet. Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. Journal of Clinical Investigation, July 2009

Cite This Page:

Journal of Clinical Investigation. "Protein That Protects Sperm, Reduces Miscarriage Rates Identified." ScienceDaily. ScienceDaily, 26 June 2009. <www.sciencedaily.com/releases/2009/06/090622171401.htm>.
Journal of Clinical Investigation. (2009, June 26). Protein That Protects Sperm, Reduces Miscarriage Rates Identified. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2009/06/090622171401.htm
Journal of Clinical Investigation. "Protein That Protects Sperm, Reduces Miscarriage Rates Identified." ScienceDaily. www.sciencedaily.com/releases/2009/06/090622171401.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How To: Mixed Green Salad Topped With Camembert Cheese

How To: Mixed Green Salad Topped With Camembert Cheese

Rumble (Jan. 26, 2015) — Learn how to make a mixed green salad topped with a pan-seared camembert cheese in only a minute! Music: Courtesy of Audio Network. Video provided by Rumble
Powered by NewsLook.com
Water Fleas Prepare for Space Voyage

Water Fleas Prepare for Space Voyage

Reuters - Innovations Video Online (Jan. 26, 2015) — Scientists are preparing a group of water fleas for a unique voyage into space. The aquatic crustaceans, known as Daphnia, can be used as a miniature model for biomedical research, and their reproductive and swimming behaviour will be tested for signs of stress while on board the International Space Station. Jim Drury went to meet the team. Video provided by Reuters
Powered by NewsLook.com
Husky Puppy Plays With Ferret

Husky Puppy Plays With Ferret

Rumble (Jan. 26, 2015) — It looks like this 2-month-old Husky puppy and the family ferret are going to be the best of friends. Look at how much fun they&apos;re having together! Credit to &apos;Vira&apos;. Video provided by Rumble
Powered by NewsLook.com
Scientists Model Flying, Walking Drone After Vampire Bats

Scientists Model Flying, Walking Drone After Vampire Bats

Buzz60 (Jan. 26, 2015) — Swiss scientists build a new drone that can both fly and walk, modeling it after the movements of common vampire bats. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins