Featured Research

from universities, journals, and other organizations

Geneticists Unearth The Roots Of Human Genetic Variation

Date:
August 4, 2009
Source:
University of Leicester
Summary:
A new study is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans. The study focuses on the process of 'recombination', which re-shuffles our genetic content at the time of egg and sperm production.

A new study at the University of Leicester is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans.

Related Articles


The study by researcher Shriparna Sarbajna focuses on the process of ‘recombination’, which re-shuffles our genetic content at the time of egg and sperm production.

This ‘re-shuffling’ creates new combinations that are passed on to future generations. Ultimately, these new combinations accumulate over many years to generate the patterns of genetic variations seen in contemporary human populations.

Doctoral research by Sarbajna uses techniques pioneered by world-renowned geneticist Professor Sir Alec Jeffreys, to analyse human sperm DNA molecules. These techniques are ultimately used to directly understand the nature, location and frequency of changes occurring in our DNA.

Sarbajna said: “These studies are enabling us to explore the very basis of human genetic variation and aiding our understanding of how errors in the process produce pathological changes like those associated with conditions such as alpha thalassaemia and Down syndrome.”

“Our research has far reaching consequences, ranging from assisting in genetic counselling through identifying factors contributing to infertility and chromosomal abnormalities, to understanding pathogenic rearrangements frequently seen in cancers and some inherited disorders.”

“Interestingly, understanding how recombination influences patterns of diversity can also shed valuable light into the history and origins of various human populations. Studying recombination is thus, not only of basic scientific importance, but also allows valuable insights into issues ranging from medicine to history and ancestry.”

“At the heart of the problem is the fact that although vast catalogues of human genetic variation now exist, little is known about the processes that give rise to these in the first place.”

This research is funded by The Royal Society, the U.K. Medical Research Council and the Louis-Jeantet Foundation.

Sarbajna recently presented her research at the Festival of Postgraduate Research, which took place on the 25th June at the University of Leicester.


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Cite This Page:

University of Leicester. "Geneticists Unearth The Roots Of Human Genetic Variation." ScienceDaily. ScienceDaily, 4 August 2009. <www.sciencedaily.com/releases/2009/06/090623150135.htm>.
University of Leicester. (2009, August 4). Geneticists Unearth The Roots Of Human Genetic Variation. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2009/06/090623150135.htm
University of Leicester. "Geneticists Unearth The Roots Of Human Genetic Variation." ScienceDaily. www.sciencedaily.com/releases/2009/06/090623150135.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Whale-Watching Scientists Spot Baby Orca

Whale-Watching Scientists Spot Baby Orca

AP (Feb. 28, 2015) Researchers following endangered killer whales spotted a baby orca off the coast of Washington state, the third birth documented this winter but still leaving the population dangerously low. (Feb. 28) Video provided by AP
Powered by NewsLook.com
The Best Drinks for Your Health

The Best Drinks for Your Health

Buzz60 (Feb. 27, 2015) When it comes to health and fitness, there&apos;s lots of talk about what foods to eat, but there are a few liquids that can promote good nutrition. Krystin Goodwin (@krystingoodwin) has the healthiest drinks to boost your health! Video provided by Buzz60
Powered by NewsLook.com
Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins