Featured Research

from universities, journals, and other organizations

Geneticists Unearth The Roots Of Human Genetic Variation

Date:
August 4, 2009
Source:
University of Leicester
Summary:
A new study is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans. The study focuses on the process of 'recombination', which re-shuffles our genetic content at the time of egg and sperm production.

A new study at the University of Leicester is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans.

The study by researcher Shriparna Sarbajna focuses on the process of ‘recombination’, which re-shuffles our genetic content at the time of egg and sperm production.

This ‘re-shuffling’ creates new combinations that are passed on to future generations. Ultimately, these new combinations accumulate over many years to generate the patterns of genetic variations seen in contemporary human populations.

Doctoral research by Sarbajna uses techniques pioneered by world-renowned geneticist Professor Sir Alec Jeffreys, to analyse human sperm DNA molecules. These techniques are ultimately used to directly understand the nature, location and frequency of changes occurring in our DNA.

Sarbajna said: “These studies are enabling us to explore the very basis of human genetic variation and aiding our understanding of how errors in the process produce pathological changes like those associated with conditions such as alpha thalassaemia and Down syndrome.”

“Our research has far reaching consequences, ranging from assisting in genetic counselling through identifying factors contributing to infertility and chromosomal abnormalities, to understanding pathogenic rearrangements frequently seen in cancers and some inherited disorders.”

“Interestingly, understanding how recombination influences patterns of diversity can also shed valuable light into the history and origins of various human populations. Studying recombination is thus, not only of basic scientific importance, but also allows valuable insights into issues ranging from medicine to history and ancestry.”

“At the heart of the problem is the fact that although vast catalogues of human genetic variation now exist, little is known about the processes that give rise to these in the first place.”

This research is funded by The Royal Society, the U.K. Medical Research Council and the Louis-Jeantet Foundation.

Sarbajna recently presented her research at the Festival of Postgraduate Research, which took place on the 25th June at the University of Leicester.


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Cite This Page:

University of Leicester. "Geneticists Unearth The Roots Of Human Genetic Variation." ScienceDaily. ScienceDaily, 4 August 2009. <www.sciencedaily.com/releases/2009/06/090623150135.htm>.
University of Leicester. (2009, August 4). Geneticists Unearth The Roots Of Human Genetic Variation. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/06/090623150135.htm
University of Leicester. "Geneticists Unearth The Roots Of Human Genetic Variation." ScienceDaily. www.sciencedaily.com/releases/2009/06/090623150135.htm (accessed July 25, 2014).

Share This




More Plants & Animals News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How to Make Single Serving Smoothies: Howdini Hacks

How to Make Single Serving Smoothies: Howdini Hacks

Howdini (July 24, 2014) Smoothies are a great way to get in lots of healthy ingredients, plus they taste great! Howdini has a trick for making the perfect single-size smoothie that will save you time on cleanup too! All you need is a blender and a mason jar. Video provided by Howdini
Powered by NewsLook.com
Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Newsy (July 24, 2014) A new study claims a set of prehistoric T-Rex footprints supports the theory that the giant predators hunted in packs instead of alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins