Featured Research

from universities, journals, and other organizations

Researchers Discover New Information On Spreading Of Cancer

Date:
July 5, 2009
Source:
Technical Research Centre of Finland (VTT)
Summary:
Researchers have discovered a mechanism lung cancer cells use when spreading into the body to form metastases. They have also found a factor controlling the spreading of several different cancer types. The common feature in both findings is that they explain the lethal ability of cancer cells to “start running” and spread from the original tumor to other parts of the body.

A joint research group of VTT Technical Research Centre of Finland and the University of Turku, led by Professor Johanna Ivaska, has discovered a mechanism lung cancer cells use when spreading into the body to form metastases.

Related Articles


The study has been published in the June 30 issue of Science Signaling.

In cooperation with the University of Heidelberg, they have also found a factor controlling the spreading of several different cancer types. The common feature in both findings is that they explain the lethal ability of cancer cells to “start running” and spread from the original tumour to other parts of the body.

Cancer is lethal because of its ability to spread into the body to form metastases. Previously, it was thought that spreading cancer cells lose the factors that bind them to other cells of the tumour, and this enables the cells to detach and migrate within the body.

Videos made by the research group’s PhD student Saara Tuomi on migrating lung cancer cells revealed to the group that the cells move using their adhesion receptors in a manner that was previously unknown. The new finding of the research group reveals that cancer cells are able to change in such a manner that a factor that previously assisted them in staying in place starts to assist the cells’ adhesion receptors and is thus the precondition needed by the cells to migrate. The group found evidence suggesting that the tumours of lung cancer patients who died because of metastases had cells that started moving using this previously unknown mechanism.

The finding opens new opportunities for the development of medicine because the migration mechanism is not vital for normal cells. The research results have been published on 30 June 2009 in the cellular biology journal Science Signaling, daughter journal of the top scientific journal Science.

The research group led by Professor Johanna Ivaska found in cooperation with researchers of the University of Heidelberg a new factor that controls the appearance of cancer cell adhesion receptors in several cancer types. The new protein has been named SCAI. The name means a cancer invasion inhibitor. The research shows that many cancers are able to eliminate the suppressing factor. This result is the cancer adding the number of its adhesion receptors on the surface of the cells and starting effective spreading. Thus, the fact that the suppressing factor is eliminated makes it possible for the cancer to spread. The research results were published in May 2009 in top scientific journal Nature Cell Biology.

When combined, these findings increase the understanding of how cancer spreads and may influence future trends in cancer research.


Story Source:

The above story is based on materials provided by Technical Research Centre of Finland (VTT). Note: Materials may be edited for content and length.


Journal References:

  1. Saara Tuomi, Anja Mai, Jonna Nevo, Jukka O. Laine, Vesa Vilkki, Tiina J. Φhman, Carl G. Gahmberg, Peter J. Parker, and Johanna Ivaska. PKCε Regulation of an α5 Integrin-ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells. Science Signaling, 2009; DOI: 10.1126/scisignal.2000135
  2. Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin. Nature Cell Biology, 2009; 11 (5): 557 DOI: 10.1038/ncb1862

Cite This Page:

Technical Research Centre of Finland (VTT). "Researchers Discover New Information On Spreading Of Cancer." ScienceDaily. ScienceDaily, 5 July 2009. <www.sciencedaily.com/releases/2009/06/090630075259.htm>.
Technical Research Centre of Finland (VTT). (2009, July 5). Researchers Discover New Information On Spreading Of Cancer. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2009/06/090630075259.htm
Technical Research Centre of Finland (VTT). "Researchers Discover New Information On Spreading Of Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/06/090630075259.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins