Featured Research

from universities, journals, and other organizations

DNA Variations Linked To Brain Tumors

Date:
July 6, 2009
Source:
Mayo Clinic
Summary:
Scientists have found a connection between DNA alterations on human chromosome 9 and aggressive brain cancer known as glioblastoma.

Mayo Clinic researchers and colleagues at the University of California San Francisco (UCSF) have found a connection between DNA alterations on human chromosome 9 and aggressive brain cancer known as glioblastoma. The findings are reported in the current online issue of Nature Genetics.

The study, conducted with different patient populations at each institution, looked for genome-wide associations using individual patient data and information in the Cancer Genome Atlas. Researchers found that persons with the specific alterations -- also known as single nucleotide polymorphisms (SNPs) -- have a 50 percent higher relative risk of developing glioblastoma.

"This is not to cause those who possess these SNPs to worry about having CT scans every year," advised Robert Jenkins, M.D. Ph.D., genetics researcher and Mayo senior author of the study. He says an individual's environment also has much to do with their risk of cancer and that such external factors may need to be present to trigger onset of brain tumors, even for those with these SNPs. "Increased relative risk is just that -- relative." A normal person's risk of developing a glioblastoma is about 1 in 10,000. The risk is about 1 in 7,000 for a person carrying one of these SNPs.

Each year between 25,000 and 30,000 persons are diagnosed with glioblastomas -- one of the most aggressive forms of brain tumor. The causes are not clear and very few who are diagnosed live beyond five years.

How the Study was Conducted

To discover genes that might indicate an increased susceptibility to glioblastomas and other types of brain tumors, the investigators searched over 250,000 variants in 692 adult glioma patients (from the San Francisco Adult Glioma Study; 70 from the Cancer Genome Atlas) and compared them to 3992 controls (3390 from Illumina Control database and 602 from the Genome Atlas). The study was then replicated using independent data from 176 glioma patients and 174 controls from Mayo Clinic. Additional reports in the same issue of Nature Genetics further support the findings with independent replication studies.

"Replication is essential in genome wide association studies," says Dr. Jenkins. "Replication across independent patient populations is critical in establishing a real association between glioblastomas and the presence of these SNPs in the genome of patients with that type of brain tumor."

Researchers on the study include Karla Ballman, Ph.D., Jan Buckner, M.D., Paul Decker, Caterina Giannini, M.D., Ph.D., Chandralekha Halder, Thomas Kollmeyer, Matthew Kosel, Daniel LaChance, M.D., Brian O'Neill, M.D., Amanda Rynearson, and Ping Yang, M.D., Ph.D., all of Mayo Clinic; Margaret Wrensch, Ph.D., Jeffrey Chang, M.D., Ph.D., Ru-Fang Yeh, Ph.D., Yuanuan Xiao, Ph.D., Mitchel Berger, M.D., Susan Chang, M.D., Lucie McCoy, Joe Patoka, Alexander Pico, Michael Prados, M.D., Terri Rice, Ivan Smirnov, Tarik Tihan, M.D., Ph.D., Joe Wiemels, Ph.D., and John Wiencke, Ph.D., all of the University of California San Francisco; and Charles Quesenberry, Ph.D., of Kaiser Permanente, Oakland.

Research was supported by the National Institutes of Health and the National Cancer Institute (including the UCSF and Mayo Clinic Brain Tumor Specialized Programs of Research Excellence (SPOREs), the National Brain Tumor Foundation, the UCSF Lewis Chair in Brain Tumor Research, the Mayo Clinic Cancer Center, the families and friends of John Berardi, Helen Glaser and Elvera Olsen, and the Bernie and Edith Waterman Foundation.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "DNA Variations Linked To Brain Tumors." ScienceDaily. ScienceDaily, 6 July 2009. <www.sciencedaily.com/releases/2009/07/090705131814.htm>.
Mayo Clinic. (2009, July 6). DNA Variations Linked To Brain Tumors. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/07/090705131814.htm
Mayo Clinic. "DNA Variations Linked To Brain Tumors." ScienceDaily. www.sciencedaily.com/releases/2009/07/090705131814.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins