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Improving Mouse Heart Function Following Heart Attack

Date:
July 22, 2009
Source:
Journal of Clinical Investigation
Summary:
One approach being developed as a way to improve heart function following heart attack is the injection of heart stem/progenitor cells directly into the heart. New research now indicates that transplanting sheets of clonally expanded heart cells expressing the protein Sca-1 (cells that are stem/progenitor cells) improves heart function after a heart attack in mice.

One approach being developed as a way to improve heart function following heart attack is the injection of heart stem/progenitor cells directly into the heart. Now, a team of researchers, at Tokyo Women's Medical University, Japan, and Chiba University Graduate School of Medicine, Japan, has found that transplanting sheets of clonally expanded heart cells expressing the protein Sca-1 (cells that are heart stem/progenitor cells and that the authors term CPCs) improves heart function after a heart attack in mice.

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The team, led by Katsuhisa Matsuura and Issei Komuro, found that CPCs not only formed heart muscle cells but also secreted a soluble molecule (sVCAM-1) that induced the migration of endothelial cells (which help form new blood vessels) and CPCs and prevented heart muscle cells dying from oxidative stress.

In the mouse model of heart attack, preventing sVCAM-1 from binding to the protein VLA-4 inhibited the formation of new blood vessels and blocked CPC migration and survival, leading to a decreased ability of the transplanted CPC sheets to improve heart function. The authors conclude that these data provide new insight into the mechanisms by which heart stem/progenitor cells improve heart function following heart attack.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. Journal of Clinical Investigation, July 13, 2009

Cite This Page:

Journal of Clinical Investigation. "Improving Mouse Heart Function Following Heart Attack." ScienceDaily. ScienceDaily, 22 July 2009. <www.sciencedaily.com/releases/2009/07/090713201437.htm>.
Journal of Clinical Investigation. (2009, July 22). Improving Mouse Heart Function Following Heart Attack. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/07/090713201437.htm
Journal of Clinical Investigation. "Improving Mouse Heart Function Following Heart Attack." ScienceDaily. www.sciencedaily.com/releases/2009/07/090713201437.htm (accessed October 25, 2014).

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