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Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy

Date:
July 22, 2009
Source:
Yale University
Summary:
In a major advance in obesity and diabetes research, scientists have found that reducing levels of a key enzyme in the brain decreased appetites and increased energy levels.

In a major advance in obesity and diabetes research, Yale School of Medicine scientists have found that reducing levels of a key enzyme in the brain decreased appetites and increased energy levels.

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Reductions in the levels of the enzyme prolylcarboxypeptidase (PRCP) led to weight loss and a decreased risk of type 2 diabetes in mice, according to new research. The team found that PRCP is located in the hypothalamus and regulates levels of the alpha-melanocyte stimulating hormone (alpha-MSH), which is a peptide known for inhibiting food intake and stimulating energy expenditure. Researchers found that blocking the PRCP enzyme keeps the alpha-MSH peptides from being degraded, resulting in higher levels of alpha-MSH and decreased appetite.

"Our research provides the first evidence that breaking down molecules in the brain that regulate metabolism is an important component of weight control," said senior author Sabrina Diano, associate professor in the Departments of Obstetrics, Gynecology and Reproductive Sciences, and Neurobiology. "Our findings provide a possible new target for the development of drugs to control metabolic disorders such as obesity and type 2 diabetes."

Diano and her team conducted the study in congenic mice that were naturally lean and later in mice that had PRCP removed. Animals without the PRCP enzyme were leaner and ate less food. They also had higher levels of alpha-MSH in the hypothalamus compared to control animals. The mice were put on a diet of 45 percent fat—the equivalent of eating fast food everyday—and even with this high fat diet, they did not gain as much weight as control animals on a regular diet.

Diano said the next step is to study how PRCP is regulated.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal References:

  1. Wallingford et al. Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI37209
  2. Richard D. Palmiter. Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI40001

Cite This Page:

Yale University. "Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy." ScienceDaily. ScienceDaily, 22 July 2009. <www.sciencedaily.com/releases/2009/07/090720190616.htm>.
Yale University. (2009, July 22). Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2009/07/090720190616.htm
Yale University. "Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy." ScienceDaily. www.sciencedaily.com/releases/2009/07/090720190616.htm (accessed March 6, 2015).

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