Featured Research

from universities, journals, and other organizations

Therapy For Parkinson's, Other Diseases Advanced With Miniaturization Of Device

Date:
July 23, 2009
Source:
DOE/Oak Ridge National Laboratory
Summary:
By miniaturizing a device that monitors the delivery of healthy cells, researchers are developing a powerful instrument for physicians to use in treating patients with Parkinson's syndrome, brain tumors and other diseases.

By miniaturizing a device that monitors the delivery of healthy cells, researchers at Department of Energy's Oak Ridge National Laboratory are developing a powerful instrument for physicians to use in treating patients with Parkinson's syndrome, brain tumors and other diseases.

Related Articles


While cell replacement therapies can be effective, the challenge is to deliver a sufficient quantity of healthy cells, said Boyd Evans III of the lab's Measurement Science and Systems Engineering Division.

"Regardless of the source of cells and the location of delivery, there is a great need to improve cell viability after the cells are transplanted," Evans said. "The vast majority of transplanted cells do not survive more than 24 hours regardless of their source."

Studies have shown that merely implanting more cells does not necessarily increase the number that survive and differentiate into dopamine-producing, or viable, cells in Parkinson's models. The key is being able to deliver precise quantities of healthy cells to a targeted location. This requires the ability to determine if the cells are viable upon delivery and the ability to make meaningful measurements. ORNL's proprietary instrumented cell delivery catheter allows physicians to do just that.

"Our approach consists of monitoring cells that are implanted using a catheter equipped with a fiber optic probe to perform fluorescence-based cytometric measurements on cells as they exit the port at the catheter tip," Evans said. These measurements confirm that the cell is alive and provide indications of the cell's health.

"What we have done is taken the function of a laboratory instrument and put it on the tip of a catheter that can make measurements inside the brain," Evans said.

Results from several studies underscore the value of delivering a highly controlled amount of tissue into the host brain, and understanding cell viability at the delivery point is critical for meaningful comparison of experimental results, according to Evans.

The instrumented catheter is part of a larger effort to develop a complete system for collecting healthy tissue from an individual who is both the donor and recipient, expanding this tissue in vitro and implanting the tissue under monitored conditions. Joining Boyd in this effort are other researchers from ORNL, George Gillies of the University of Virginia, and neurosurgeon William Broaddus and neuroscientist Helen Fillmore of Virginia Commonwealth University.

Funding provided through ORNL's Laboratory Directed Research and Development program was used to develop a prototype device and demonstrate its functionality for characterizing cell flows of cell.

Following completion of the LDRD funded project, NexGen Medical Systems and Kopf Family Foundation at the University of Virginia, and the Cullather, Hord and Hafner Funds at Virginia Commonwealth University worked on other issues associated with flows of slurries of cells, such as cell delivery, cell selection and culturing technique.


Story Source:

The above story is based on materials provided by DOE/Oak Ridge National Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

DOE/Oak Ridge National Laboratory. "Therapy For Parkinson's, Other Diseases Advanced With Miniaturization Of Device." ScienceDaily. ScienceDaily, 23 July 2009. <www.sciencedaily.com/releases/2009/07/090722165503.htm>.
DOE/Oak Ridge National Laboratory. (2009, July 23). Therapy For Parkinson's, Other Diseases Advanced With Miniaturization Of Device. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/07/090722165503.htm
DOE/Oak Ridge National Laboratory. "Therapy For Parkinson's, Other Diseases Advanced With Miniaturization Of Device." ScienceDaily. www.sciencedaily.com/releases/2009/07/090722165503.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins