Featured Research

from universities, journals, and other organizations

Common Household Pesticides Linked To Childhood Cancer Cases In Washington Area

Date:
August 4, 2009
Source:
Georgetown University Medical Center
Summary:
Researchers find a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia, a cancer that develops most commonly between three and seven years of age. The findings should not be seen as cause-and-effect, but suggests an association between pesticide exposure and development of childhood ALL.

A new study by researchers at the Georgetown's Lombardi Comprehensive Cancer Center finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops most commonly between three and seven years of age. The findings are published in the August issue of the journal Therapeutic Drug Monitoring.

Related Articles


Researchers caution that these findings should not be seen as cause-and-effect, only that the study suggests an association between pesticide exposure and development of childhood ALL.

"In our study, we compared urine samples from children with ALL and their mothers with healthy children and their moms. We found elevated levels of common household pesticides more often in the mother-child pairs affected by cancer," says the study's lead investigator, Offie Soldin, PhD, an epidemiologist at Lombardi. Soldin cautions, "We shouldn't assume that pesticides caused these cancers, but our findings certainly support the need for more robust research in this area."

The study was conducted between January 2005 and January 2008 with volunteer participants from Lombardi and Children's National Medical Center who live in the Washington metropolitan area. It included 41 pairs of children with ALL and their mothers (cases), and 41 pairs of healthy children and their mothers (controls). For comparison purposes, the case pairs were matched with control pairs by age, sex and county of residence. Previous studies in agricultural areas of the country have suggested a relationship between pesticides and childhood cancers, but researchers say this is the first study conducted in a large, metropolitan area.

Urine samples were collected from all child-mother pairs and analyzed by the Centers for Disease Control and Prevention to look for evidence of organophosphates (OP), the chemical name of some household pesticides. The body breaks down OP into metabolites which can be tracked in urine samples. The researchers say pesticides were detected in the urine of more than half of the participants, but levels of two common OP metobolites, diethylthiophosphate (DETP) and diethyldithiophosphate (DEDTP), were higher in the children with ALL compared to the control children (p< 0.03 and p< 0.05).

Also for the study, the mothers completed a questionnaire to collect information about the family's exposure to pesticides, their medical history, home and neighborhood characteristics, diet, and history of smoke exposure. More case mothers (33 percent) than controls (14 percent) reported using insecticides in the home (p< 0.02), however there was no correlation found between high levels of the OP metabolites in urine and reported use of pesticides.

"We know pesticides – sprays, strips, or 'bombs,' are found in at least 85 percent of households, but obviously not all the children in these homes develop cancer. What this study suggests is an association between pesticide exposure and the development of childhood ALL, but this isn't a cause-and-effect finding," Soldin explains. "Future research would help us understand the exact role of pesticides in the development of cancer. We hypothesize that pre-natal exposure coupled with genetic susceptibility or an additional environmental insult after birth could be to blame."

The study was funded by Lombardi's Cancer Center Support Grant from the National Cancer Institute, and by philanthropic support from Debbie and Scott Amey.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Common Household Pesticides Linked To Childhood Cancer Cases In Washington Area." ScienceDaily. ScienceDaily, 4 August 2009. <www.sciencedaily.com/releases/2009/07/090728102306.htm>.
Georgetown University Medical Center. (2009, August 4). Common Household Pesticides Linked To Childhood Cancer Cases In Washington Area. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2009/07/090728102306.htm
Georgetown University Medical Center. "Common Household Pesticides Linked To Childhood Cancer Cases In Washington Area." ScienceDaily. www.sciencedaily.com/releases/2009/07/090728102306.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins