Featured Research

from universities, journals, and other organizations

Altered Micriobiome Prevalent In Diseased Esophagus

Date:
August 20, 2009
Source:
NYU Langone Medical Center / New York University School of Medicine
Summary:
Gastroesophageal reflux diseases, or GERD, affects about 10 million people in the United States, yet the cause and an unexpected increase in its prevalence over the last three decades remains unexplainable.

Gastroesophageal reflux diseases , or GERD, affects about 10 million people in the United States, yet the cause and an unexpected increase in its prevalence over the last three decades remains unexplainable. Now, researchers have discovered that GERD is associated with global alteration of the microbiome in the esophagus. The findings, reported in the August 1, 2009 issue of Gastroenterology, may provide for the foundation for further study of the condition as a microecological disease with new treatment possibilities.

The findings of an altered microbiome may have profound implications for treating diseases of the esophagus, among the most common disorders affecting Western populations. In fact, about 40% of adults experience heartburn symptoms at least once a month. Chronic inflammation associated with GERD can lead to the development of Barrett's esophagus, precancerous condition. The incidence of cancer of the esophagus has increased six-fold since the 1970s--the fastest increasing cancer in the Western world.

"These findings have opened a new approach to understanding the pathogenesis of reflux-related disorders," states Zhiheng Pei, MD, PhD, assistant professor of pathology and medicine at NYU Langone Medical Center and lead author of the study. "At this time, we don't yet know whether the changes in bacterial populations are triggering GERD or are simply a response to it. But if changes in the bacterial population do indeed cause reflux, it may be possible to design new therapies with antibiotics, probiotic bacteria or prebiotics."

Researchers collected and sequenced bacteria from the esophagus of 34 patients, both healthy and those suffering from GERD (specifically esophagitis and Barrett's esophagus). They found a high concentration of Streptococcus in the esophagus of healthy patients. In contrast, an altered type of microbiome dominated by Gram-negative bacteria was contained in greater proportions in those patients with esophagitis and Barrett's esophagus.

The human microbiome is comprised of all the microorganisms that reside in or on the human body, as well as all their DNA, or genomes. Microbial cells in the human body are estimated to outnumber human cells by a factor of ten to one. These communities, or microbiomes, however remain largely unstudied, leaving almost entirely unknown their influence upon human development, physiology, immunity and nutrition.

In order to analyze the makeup of these microbial organisms, the National Institutes of Health (NIH) launched the Human Microbiome Project in 2007 and awarded $115 million in research grants over five years to examine the relationship between the microbiome in a specific niche in the body to a particular disease. This study was sponsored by the NIH to examine how changes in microbioal populations correlate with changes in human health.


Story Source:

The above story is based on materials provided by NYU Langone Medical Center / New York University School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

NYU Langone Medical Center / New York University School of Medicine. "Altered Micriobiome Prevalent In Diseased Esophagus." ScienceDaily. ScienceDaily, 20 August 2009. <www.sciencedaily.com/releases/2009/08/090801092710.htm>.
NYU Langone Medical Center / New York University School of Medicine. (2009, August 20). Altered Micriobiome Prevalent In Diseased Esophagus. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2009/08/090801092710.htm
NYU Langone Medical Center / New York University School of Medicine. "Altered Micriobiome Prevalent In Diseased Esophagus." ScienceDaily. www.sciencedaily.com/releases/2009/08/090801092710.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins