Featured Research

from universities, journals, and other organizations

Cardiovascular Diseases: Researchers Have Found A Way To Treat Ischemic Pathologies

Date:
August 18, 2009
Source:
Basque Research
Summary:
Scientists have developed a new area of research which looks extremely promising regarding the development of new therapeutic responses to ischemic pathologies and cardiovascular diseases in general.

A team of researchers from CIC bioGUNE from the Cellular Biology and Stem Cell Unit, alongside a team from Paris’ Cardiovascular Research Centre (INSERM U970) have developed a new area of research which looks extremely promising regarding the development of new therapeutic responses to ischemic pathologies and cardiovascular diseases in general.

Related Articles


The results of this research project, which was initiated in 2005 and is supported by Bizkaia:Xede and the Basque Government’s Etortek programme, were published in the journal Circulation.

By activating a protein called HIF, the strategy is to stimulate revascularisation and the repair of the damaged organ following ischemia caused by the obstruction of a blood vessel preventing normal blood flow. These obstructions occur, for example, in the event of thrombosis in a limb, myocardial infarction or a stroke. In this sense, it is important to highlight the fact that cardiovascular diseases are the principal cause of death throughout the world (in the European Union, they account for 40% of all deaths, a figure equivalent to 2 million deaths per year).

In general, cells tend to respond to the lack of oxygen caused by poor blood flow by activating HIF. However, in the case of an ischemic pathology, HIF is not sufficiently activated.

Dr Berra, Cellular Biology and Stem Cell Unit’s leader, stated that they decided to over-produce HIF following ischemia as an attractive therapeutic alternative. For their research purposes, they used an ischemic model provoked in a mouse leg through ligation of the femoral artery. In other words, they closed off the femoral artery and stopped the blood flow to the limb. When this happens, the leg develops necrosis and after a time, the mouse dies.

The aim was to artificially help stimulate the production of HIF after the femoral artery had been closed off. And they saw that when they did this, the mouse’s leg revascularised and no longer entered into a degenerative process.

How is this high level of HIF production achieved? HIF is a protein which, when not required, degrades constitutively and this degradation is regulated by enzymes called PHDs.

These enzymes hydroxylate HIF and, as a result of this hydroxylation, the protein degrades. Therefore, when these enzymes are inhibited, HIF cannot degrade and so accumulates. To inhibit PHDs, they use siRNAs, explains Dr Berra.


Story Source:

The above story is based on materials provided by Basque Research. Note: Materials may be edited for content and length.


Cite This Page:

Basque Research. "Cardiovascular Diseases: Researchers Have Found A Way To Treat Ischemic Pathologies." ScienceDaily. ScienceDaily, 18 August 2009. <www.sciencedaily.com/releases/2009/08/090805075753.htm>.
Basque Research. (2009, August 18). Cardiovascular Diseases: Researchers Have Found A Way To Treat Ischemic Pathologies. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/08/090805075753.htm
Basque Research. "Cardiovascular Diseases: Researchers Have Found A Way To Treat Ischemic Pathologies." ScienceDaily. www.sciencedaily.com/releases/2009/08/090805075753.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins