Featured Research

from universities, journals, and other organizations

Radiation Therapy May Increase Diabetes Risk In Childhood Cancer Survivors

Date:
August 11, 2009
Source:
JAMA and Archives Journals
Summary:
Childhood cancer survivors treated with total body or abdominal radiation may have an increased risk of diabetes, according to a new report. This correlation does not appear to be related to patients' body mass index or physical inactivity.

Childhood cancer survivors treated with total body or abdominal radiation may have an increased risk of diabetes, according to a report in the August 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. This correlation does not appear to be related to patients' body mass index or physical inactivity.

"As a result of their curative therapies, childhood cancer survivors face an increased risk of morbidity and mortality," with almost 75 percent of survivors developing a chronic health condition and 42.4 percent developing a severe, disabling or life-threatening condition 30 years after diagnosis, according to background information in the article. Cardiovascular disease, in particular, is a significant cause of deaths in this group. "In the general population, diabetes mellitus is strongly associated with an increased risk of cardiovascular disease and all-cause death."

Lillian R. Meacham, M.D., of Emory University and AFLAC Cancer Center and Blood Disorders Service, Atlanta, and colleagues compared the prevalence of diabetes in a sample of 8,599 childhood cancer survivors (diagnosed before age 21 between 1970 and 1986) and 2,936 randomly selected siblings of the survivors (average ages 31.5 and 33.4 at follow-up in 2003, respectively). Medication use, treatment exposures (including irradiation, or exposure to radiation treatments) and factors that may have modified the risk of diabetes were noted.

Of the survivors, 218 (2.5 percent) reported having diabetes, while 49 (1.7 percent) of siblings reported having the condition. "After adjustment for body mass index, age, sex, race/ethnicity, household income and insurance, the survivors were 1.8 times more likely than the siblings to report diabetes mellitus, with survivors who received total body irradiation, abdominal irradiation and cranial irradiation at increased risk," the authors write. "Survivors who were treated with abdominal irradiation were 2.7 times as likely to report diabetes mellitus as those who were not treated with abdominal irradiation or total body irradiation; those treated with total body irradiation were 7.2 times as likely to report diabetes mellitus."

Survivors diagnosed with cancer before age 5 were 2.4 times more likely to report diabetes than those diagnosed in late adolescence (from ages 15 to 20). "As in the general population, older age, black or Hispanic/Latino background, lower household income, physical inactivity and increased BMI were associated with an increased risk of diabetes mellitus," they note.

"It is likely that this additional chronic disease in childhood cancer survivors, who frequently also sustain damage to the heart, kidneys and endocrine system, will lead to further morbidity and premature mortality," the authors conclude. "Therefore, it is imperative that clinicians recognize this risk, screen for diabetes and prediabetes when appropriate and approach survivors with aggressive risk-reducing strategies. Moreover, further research is warranted to understand the pathways by which these two modes of radiation therapy lead to diabetes."

This work was supported by a grant from the Department of Health and Human Services, by funding to the University of Minnesota from the Children's Cancer Research Fund and by funding to St. Jude Children's Research Hospital from the American Lebanese Syrian Associated Charities (ALSAC).


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lillian R. Meacham; Charles A. Sklar; Suwen Li; Qi Liu; Nora Gimpel; Yutaka Yasui; John A. Whitton; Marilyn Stovall; Leslie L. Robison; Kevin C. Oeffinger. Diabetes Mellitus in Long-term Survivors of Childhood Cancer: Increased Risk Associated With Radiation Therapy: A Report for the Childhood Cancer Survivor Study. Arch Intern Med., 2009; 169 (15): 1381-1388

Cite This Page:

JAMA and Archives Journals. "Radiation Therapy May Increase Diabetes Risk In Childhood Cancer Survivors." ScienceDaily. ScienceDaily, 11 August 2009. <www.sciencedaily.com/releases/2009/08/090810161911.htm>.
JAMA and Archives Journals. (2009, August 11). Radiation Therapy May Increase Diabetes Risk In Childhood Cancer Survivors. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/08/090810161911.htm
JAMA and Archives Journals. "Radiation Therapy May Increase Diabetes Risk In Childhood Cancer Survivors." ScienceDaily. www.sciencedaily.com/releases/2009/08/090810161911.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins