Featured Research

from universities, journals, and other organizations

Seizures During Pregnancy Associated With Risk Of Pre-term And Small Babies

Date:
August 12, 2009
Source:
JAMA and Archives Journals
Summary:
Women with epilepsy who have seizures during pregnancy appear more likely to give birth to pre-term, small or low-birth-weight babies than women without epilepsy, according to a new report.

Women with epilepsy who have seizures during pregnancy appear more likely to give birth to pre-term, small or low-birth-weight babies than women without epilepsy, according to a report in the August issue of Archives of Neurology, one of the JAMA/Archives journals.

An estimated 0.2 percent to 0.7 percent of pregnant women have epilepsy, the most common major neurologic complication in pregnancy, according to background information in the article. "While approximately 40 percent of the 18 million women with epilepsy in the world are of childbearing age, managing maternal epilepsy and monitoring the health of the developing fetus remain some of the most perplexing and engaging issues in the fields of neurology and obstetrics," the authors write.

Yi-Hua Chen, Ph.D., of Tai Pei Medical University, Taiwan, and colleagues used data from the Taiwan National Health Insurance Research Data set and analyzed records from 1,016 women with epilepsy who gave birth between 2001 and 2003. Of these, 503 had seizures during pregnancy and 513 did not. A control group of 8,128 women who were the same age and gave birth during the same years but did not have epilepsy or any other chronic disease were selected for comparison.

Compared to women without epilepsy, women who had seizures during pregnancy had a 1.36-fold greater risk of having a low-birth-weight baby (weighing less than 2,500 grams), a 1.63-fold increased risk of giving birth pre-term (before 37 weeks) and a 1.37-fold increased risk of having a baby who was small for gestational age (having a birth weight below the 10th percentile for age). In addition, when compared with women who had epilepsy but did not have seizures, the odds of women who had seizures during pregnancy having a baby who was small for gestational age were 1.34 times greater.

Some previous studies had reported a link between adverse pregnancy outcomes and mothers' epilepsy, but others found no association, the authors note. "Our study further illuminates these conflicting data to suggest that it is the seizures themselves that seem to contribute greatly to the increased risk of infants being delivered preterm, of low birth weight and small for gestational age. For women who remained seizure-free throughout pregnancy, null or mild risk was identified compared with unaffected women."

Several mechanisms might explain the association between seizures and adverse pregnancy outcomes. Trauma caused by a woman's seizures could rupture fetal membranes, increasing risk of infection and early delivery. Tension and acute injury may result from contractions in the uterus that occur during seizures. However, additional research is needed to understand how seizures interfere with fetal development.

"Neonates born pre-term, of low birth weight and small for gestational age may be predisposed to diseases during infancy and later life, highlighting the significance of proper intervention strategies for prevention," the authors write. These could include helping women control seizures for a period of time before pregnancy, assisting them in sleeping better, providing education about the risks of seizures while pregnant and teaching improved strategies for coping with stress.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yi-Hua Chen; Hung-Yi Chiou; Herng-Ching Lin; Hsiu-Li Lin. Affect of Seizures During Gestation on Pregnancy Outcomes in Women With Epilepsy. Arch Neurol., 2009; 66 (8): 979-984 [link]

Cite This Page:

JAMA and Archives Journals. "Seizures During Pregnancy Associated With Risk Of Pre-term And Small Babies." ScienceDaily. ScienceDaily, 12 August 2009. <www.sciencedaily.com/releases/2009/08/090810161913.htm>.
JAMA and Archives Journals. (2009, August 12). Seizures During Pregnancy Associated With Risk Of Pre-term And Small Babies. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2009/08/090810161913.htm
JAMA and Archives Journals. "Seizures During Pregnancy Associated With Risk Of Pre-term And Small Babies." ScienceDaily. www.sciencedaily.com/releases/2009/08/090810161913.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins