Featured Research

from universities, journals, and other organizations

Study identifies risk factors for transformation of eye growths into melanoma

Date:
August 12, 2009
Source:
JAMA and Archives Journals
Summary:
Eight factors may predict whether a choroidal nevus -- a benign, flat, pigmented growth inside the eye and beneath the retina -- may develop into melanoma, according to a new report.

Eight factors may predict whether a choroidal nevus—a benign, flat, pigmented growth inside the eye and beneath the retina—may develop into melanoma, according to a report in the August issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

"There is strong interest for early detection of choroidal melanoma [a malignant growth], and its differentiation from nevus continues to be the major impediment," the authors write as background information in the article. Benign choroidal nevi and small melanomas share many characteristics, including color, location and size. "The challenge is to identify the single small melanoma among the thousands of choroidal nevi. It has been estimated that 6 percent of the white population harbors a choroidal nevus and that one in approximately 8,000 of these nevi transform into melanoma."

Carol L. Shields, M.D., and colleagues at Wills Eye Institute, Thomas Jefferson University, Philadelphia, studied the medical records of 2,514 consecutive eyes of patients with choroidal nevi between 1974 and 2006. The tumors had a median (midpoint) diameter of 5 millimeters and a median thickness of 1.5 millimeters at the beginning of the study. Choroidal nevi grew into melanoma in a total of 180 eyes (7 percent) over an average follow-up of 53 months, including 2 percent after one year, 9 percent after five years and 13 percent after ten years.

The factors that predicted growth into melanoma included five previously identified factors: tumor thickness greater than 2 millimeters, fluid beneath the retina, symptoms such as decreased vision or flashes and floaters, orange pigment and a tumor edge within 3 millimeters of the optic disc. Two new factors were also identified: hollowness of the growth on ultrasound and the absence of a surrounding halo, or circular band of depigmentation.

"Until systemic therapies for metastastic uveal melanoma improve, our focus should be on early detection to minimize metastastic disease," the authors write. "All ophthalmologists should participate in this effort and patients with risk factors can be referred for evaluation at centers familiar with the nuances in the diagnosis and management of early melanoma."

Patients with choroidal nevi that do not display any of the seven features of disease should be monitored twice yearly at first and then followed up yearly if their condition remains stable; those with one or two features should be monitored every four to six months; and those with three or more features should be evaluated at an experienced center for possible treatment, they conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carol L. Shields; Minoru Furuta; Edwina L. Berman; Jonathan D. Zahler; Daniel M. Hoberman; Diep H. Dinh; Arman Mashayekhi; Jerry A. Shields. Choroidal Nevus Transformation Into Melanoma: Analysis of 2514 Consecutive Cases. Arch Ophthalmol., 2009; 127 (8): 981-987 [link]

Cite This Page:

JAMA and Archives Journals. "Study identifies risk factors for transformation of eye growths into melanoma." ScienceDaily. ScienceDaily, 12 August 2009. <www.sciencedaily.com/releases/2009/08/090810161915.htm>.
JAMA and Archives Journals. (2009, August 12). Study identifies risk factors for transformation of eye growths into melanoma. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2009/08/090810161915.htm
JAMA and Archives Journals. "Study identifies risk factors for transformation of eye growths into melanoma." ScienceDaily. www.sciencedaily.com/releases/2009/08/090810161915.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins