Featured Research

from universities, journals, and other organizations

To Contract Or Not To Contract: Decision Controlled By 2 MicroRNAs

Date:
September 10, 2009
Source:
Journal of Clinical Investigation
Summary:
New research has provided insight into the molecular regulators of the function of muscle cells in the walls of blood vessels, i.e., vascular smooth muscle cells. Specifically, the acquisition and/or maintenance of the ability of VSMCs to contract and relax, thereby modulating blood pressure and distributing blood to the areas of the body that need it most, was found to be controlled in mice by two small RNA molecules known miR-143 and miR-145.

New research has provided insight into the molecular regulators of the function of muscle cells in the walls of blood vessels, i.e., vascular smooth muscle cells. Specifically, the acquisition and/or maintenance of the ability of VSMCs to contract and relax, thereby modulating blood pressure and distributing blood to the areas of the body that need it most, was found to be controlled in mice by two small RNA molecules known miR-143 and miR-145.

The walls of blood vessels contain muscle cells known as vascular smooth muscle cells (VSMCs). These cells contract and relax to modulate blood pressure and distribute blood to the areas of the body that need it most. However, some environmental signals, many of which are associated with human disease, cause VSMCs to switch from being contractile in nature to being dividing cells that produce large amounts of the proteins that form tissue matrix.

Despite the fact that this switch has been associated with a number of human blood vessel diseases, the mechanisms that control it have not been well defined. However, a team of researchers at the Max-Planck-Institut für Herz- und Lungenforschung, Germany, has now identified two small RNA molecules (microRNAs) known miR-143 and miR-145 that regulate acquisition and/or maintenance of the contractile nature of VSMCs in mice.

The team, led by Thomas Braun and Thomas Boettger, generated mice lacking both miR-143 and miR-145 and found that they had dramatically reduced numbers of contractile VSMCs and increased numbers of tissue matrix–producing VSMCs in their large arterial blood vessels. Further analysis revealed that these two small RNA molecules were required for normal contractility of arteries in vitro and maintenance of normal blood pressure in vivo. As their absence led to signs of blood vessel disease in mice, the authors suggest that miR-143/145 might provide new therapeutic targets to enhance blood vessel repair and attenuate blood vessel disease.

In an accompanying commentary, Michael Parmacek, at the University of Pennsylvania School of Medicine, Philadelphia, discusses the importance of this study and highlights the fact that miR-143 and miR-145 were found to alter the expression of differing sets of genes, meaning that future studies will need to determine precisely how they alter control of blood pressure and disease development.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. Journal of Clinical Investigation, August 17, 2009

Cite This Page:

Journal of Clinical Investigation. "To Contract Or Not To Contract: Decision Controlled By 2 MicroRNAs." ScienceDaily. ScienceDaily, 10 September 2009. <www.sciencedaily.com/releases/2009/08/090817184447.htm>.
Journal of Clinical Investigation. (2009, September 10). To Contract Or Not To Contract: Decision Controlled By 2 MicroRNAs. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/08/090817184447.htm
Journal of Clinical Investigation. "To Contract Or Not To Contract: Decision Controlled By 2 MicroRNAs." ScienceDaily. www.sciencedaily.com/releases/2009/08/090817184447.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) — Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) — New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins