Featured Research

from universities, journals, and other organizations

Cellular Crosstalk Linked To Lung Disease

Date:
September 1, 2009
Source:
Journal of Clinical Investigation
Summary:
Crosstalk between cells lining the lung and airway smooth muscle cells is important in lung development. However, it has also been shown to contribute to several lung diseases, including asthma and pulmonary hypertension. Researchers have now molecularly characterized one crosstalk pathway in mice, providing potential new therapeutic targets for treating individuals with lung diseases caused by affects on airway smooth muscle cells, such as asthma and pulmonary hypertension.

Crosstalk between cells lining the lung (epithelial cells) and airway smooth muscle cells is important in lung development. However, it has also been shown to contribute to several lung diseases, including asthma and pulmonary hypertension.

A team of researchers, at the University of Pennsylvania, Philadelphia, has now molecularly characterized one crosstalk pathway in mice, providing potential new therapeutic targets for treating individuals with lung diseases, such as asthma and pulmonary hypertension, which are caused, at least in part, by affects on airway smooth muscle cells.

The team, led by Edward Morrisey and Ethan David Cohen, used numerous in vivo gain- and loss-of-function approaches to demonstrate that a Wnt7b/Tnc/Pdgfr crosstalk pathway was important for mouse smooth muscle development, with Wnt7b being exclusively expressed by lung epithelial cells and Pdgfr being expressed by the developing airway smooth muscle cells.

Importantly, expression of the components of this crosstalk pathway was upregulated in a mouse model of asthma and humans with pulmonary hypertension, thereby identifying the Wnt/Tnc/Pdgfr crosstalk pathway as important in both lung development and adult lung disease.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cohen et al. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI38079

Cite This Page:

Journal of Clinical Investigation. "Cellular Crosstalk Linked To Lung Disease." ScienceDaily. ScienceDaily, 1 September 2009. <www.sciencedaily.com/releases/2009/08/090817184449.htm>.
Journal of Clinical Investigation. (2009, September 1). Cellular Crosstalk Linked To Lung Disease. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/08/090817184449.htm
Journal of Clinical Investigation. "Cellular Crosstalk Linked To Lung Disease." ScienceDaily. www.sciencedaily.com/releases/2009/08/090817184449.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins