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MicroRNA In Human Saliva May Help Diagnose Oral Cancer

Date:
August 26, 2009
Source:
American Association for Cancer Research
Summary:
Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to new research.

Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"It is a Holy Grail of cancer detection to be able to measure the presence of a cancer without a biopsy, so it is very appealing to think that we could detect a cancer-specific marker in a patient's saliva," said Jennifer Grandis, M.D., professor of otolaryngology and pharmacology at the University of Pittsburgh School of Medicine and Cancer Institute and a senior editor of Clinical Cancer Research.

MicroRNAs are molecules produced in cells that have the ability to simultaneously control activity and assess the behavior of multiple genes. They are a thriving research topic right now, and researchers believe they could hold the key to early detection of cancer. The emergence of a microRNA profile in saliva represents a major step forward in the early detection of oral cancer.

"The oral cavity is a mirror to systemic health, and many diseases that develop in other parts of the body have an oral manifestation," said David T. Wong, D.M.D., D.M.Sc., Felix and Mildred Yip Endowed Professor at the University of California, Los Angeles School of Dentistry.

Wong and colleagues measured microRNA levels in the saliva of 50 patients with oral squamous cell carcinoma and 50 healthy control patients. They detected approximately 50 microRNAs.

Two specific microRNAs, miR-125a and miR-200a, were present at significantly lower levels in patients with oral cancer than in the healthier controls.

Wong said that the findings of this study would have to be confirmed by a larger and longer analysis.


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The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "MicroRNA In Human Saliva May Help Diagnose Oral Cancer." ScienceDaily. ScienceDaily, 26 August 2009. <www.sciencedaily.com/releases/2009/08/090825150958.htm>.
American Association for Cancer Research. (2009, August 26). MicroRNA In Human Saliva May Help Diagnose Oral Cancer. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/08/090825150958.htm
American Association for Cancer Research. "MicroRNA In Human Saliva May Help Diagnose Oral Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/08/090825150958.htm (accessed September 2, 2014).

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